WWW.LI.I-DOCX.RU
БЕСПЛАТНАЯ  ИНТЕРНЕТ  БИБЛИОТЕКА - Различные ресурсы
 

Pages:     | 1 |   ...   | 8 | 9 || 11 | 12 |   ...   | 17 |

«Антипролиферативное действие карнозина и его производных на опухолевые клетки нейрального происхождения ...»

-- [ Страница 10 ] --

ADDIN EN.CITE.DATA [7]Карнозин-синтетаза относится к семейству ATP-grasp ферментов, катализирующих АТФ-зависимое присоединение карбоксила одной молекулы к амино- или тиоловой группе другой с образованием АДФ и органического фосфата (Pi) ADDIN EN.CITE <EndNote><Cite><Author>Galperin</Author><Year>1997</Year><RecNum>328</RecNum><DisplayText>[185]</DisplayText><record><rec-number>328</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">328</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Galperin, M. Y.</author><author>Koonin, E. V.</author></authors></contributors><auth-address>National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA. galperin@ncbi.nlm.nih.gov</auth-address><titles><title>A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity</title><secondary-title>Protein Sci</secondary-title><alt-title>Protein science : a publication of the Protein Society</alt-title></titles><periodical><full-title>Protein Sci</full-title><abbr-1>Protein science : a publication of the Protein Society</abbr-1></periodical><alt-periodical><full-title>Protein Sci</full-title><abbr-1>Protein science : a publication of the Protein Society</abbr-1></alt-periodical><pages>2639-43</pages><volume>6</volume><number>12</number><edition>1998/01/07</edition><keywords><keyword>Adenosine Triphosphate/metabolism/ pharmacology</keyword><keyword>Amino Acid Sequence</keyword><keyword>Binding Sites</keyword><keyword>Carbon-Nitrogen Ligases/ chemistry/ metabolism</keyword><keyword>Conserved Sequence</keyword><keyword>Molecular Sequence Data</keyword><keyword>Sequence Alignment</keyword><keyword>Sequence Analysis</keyword><keyword>Structure-Activity Relationship</keyword></keywords><dates><year>1997</year><pub-dates><date>Dec</date></pub-dates></dates><isbn>0961-8368 (Print)&#xD;0961-8368 (Linking)</isbn><accession-num>9416615</accession-num><urls></urls><custom2>PMC2143612</custom2><electronic-resource-num>10.1002/pro.5560061218</electronic-resource-num><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[185]. Ген карнозин-синтетазы располагается в 11q13 хромосоме человека и экспрессируется главным образом в мозге и мышцах PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ecm96YWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+MTU1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3XTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4xNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE1NTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RHJvemFrLCBKLjwvYXV0aG9yPjxhdXRob3I+

VmVpZ2EtZGEtQ3VuaGEsIE0uPC9hdXRob3I+PGF1dGhvcj5WZXJ0b21tZW4sIEQuPC9hdXRob3I+





PGF1dGhvcj5TdHJvb2JhbnQsIFYuPC9hdXRob3I+PGF1dGhvcj5WYW4gU2NoYWZ0aW5nZW4sIEUu

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TGFib3JhdG9y

eSBvZiBQaHlzaW9sb2dpY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0ZSBDYXRob2xpcXVlIGRlIExv

dXZhaW4sIEF2ZW51ZSBIaXBwb2NyYXRlIDc1LCBCLTEyMDAgQnJ1c3NlbHMsIEJlbGdpdW0uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TW9sZWN1bGFyIGlkZW50aWZpY2F0aW9uIG9mIGNh

cm5vc2luZSBzeW50aGFzZSBhcyBBVFAtZ3Jhc3AgZG9tYWluLWNvbnRhaW5pbmcgcHJvdGVpbiAx

IChBVFBHRDEpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9mdWxs

LXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2FiYnIt

MT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45MzQ2LTU2PC9wYWdlcz48dm9sdW1lPjI4NTwv

dm9sdW1lPjxudW1iZXI+MTM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzAxLzI2PC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgTW9ub3Bob3NwaGF0ZS9tZXRhYm9saXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvIGNoZW1pc3RyeTwva2V5d29yZD48

a2V5d29yZD5BbGFuaW5lL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5BbWlubyBBY2lkIFNl

cXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9z

aW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBMaW5lPC9rZXl3b3JkPjxrZXl3

b3JkPkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5N

YXNzIFNwZWN0cm9tZXRyeS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdvcmQ+

PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+UGVwdGlk

ZSBTeW50aGFzZXMvIGdlbmV0aWNzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRp

ZGVzL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBIb21vbG9neSwgQW1pbm8g

QWNpZDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtl

eXdvcmQ+Z2FtbWEtQW1pbm9idXR5cmljIEFjaWQvY2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXIgMjY8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDgzLTM1MVggKEVsZWN0cm9uaWMpJiN4RDswMDIx

LTkyNTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMDk3NzUyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMyODQzMTgzPC9jdXN0b20yPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMTA5LjA5NTUwNTwvZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ecm96YWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+MTU1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3XTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4xNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE1NTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RHJvemFrLCBKLjwvYXV0aG9yPjxhdXRob3I+

VmVpZ2EtZGEtQ3VuaGEsIE0uPC9hdXRob3I+PGF1dGhvcj5WZXJ0b21tZW4sIEQuPC9hdXRob3I+





PGF1dGhvcj5TdHJvb2JhbnQsIFYuPC9hdXRob3I+PGF1dGhvcj5WYW4gU2NoYWZ0aW5nZW4sIEUu

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TGFib3JhdG9y

eSBvZiBQaHlzaW9sb2dpY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0ZSBDYXRob2xpcXVlIGRlIExv

dXZhaW4sIEF2ZW51ZSBIaXBwb2NyYXRlIDc1LCBCLTEyMDAgQnJ1c3NlbHMsIEJlbGdpdW0uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TW9sZWN1bGFyIGlkZW50aWZpY2F0aW9uIG9mIGNh

cm5vc2luZSBzeW50aGFzZSBhcyBBVFAtZ3Jhc3AgZG9tYWluLWNvbnRhaW5pbmcgcHJvdGVpbiAx

IChBVFBHRDEpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9mdWxs

LXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2FiYnIt

MT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45MzQ2LTU2PC9wYWdlcz48dm9sdW1lPjI4NTwv

dm9sdW1lPjxudW1iZXI+MTM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzAxLzI2PC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgTW9ub3Bob3NwaGF0ZS9tZXRhYm9saXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvIGNoZW1pc3RyeTwva2V5d29yZD48

a2V5d29yZD5BbGFuaW5lL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5BbWlubyBBY2lkIFNl

cXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9z

aW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBMaW5lPC9rZXl3b3JkPjxrZXl3

b3JkPkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5N

YXNzIFNwZWN0cm9tZXRyeS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdvcmQ+

PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+UGVwdGlk

ZSBTeW50aGFzZXMvIGdlbmV0aWNzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRp

ZGVzL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBIb21vbG9neSwgQW1pbm8g

QWNpZDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtl

eXdvcmQ+Z2FtbWEtQW1pbm9idXR5cmljIEFjaWQvY2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXIgMjY8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDgzLTM1MVggKEVsZWN0cm9uaWMpJiN4RDswMDIx

LTkyNTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMDk3NzUyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMyODQzMTgzPC9jdXN0b20yPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMTA5LjA5NTUwNTwvZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [7]. Bauer et al. показали, что карнозин и его производные синтезируется в основном клетками глии. Интересно, что опухолевые клетки, глиомы С6, тоже активно синтезировали карнозин и родственные соединения ADDIN EN.CITE <EndNote><Cite><Author>Bauer</Author><Year>1979</Year><RecNum>343</RecNum><DisplayText>[186]</DisplayText><record><rec-number>343</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">343</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Bauer, K.</author><author>Salnikow, J.</author><author>de Vitry, F.</author><author>Tixier-Vidal, A.</author><author>Kleinkauf, H.</author></authors></contributors><titles><title>Characterization and biosynthesis of omega-aminoacyl amino acids from rat brain and the C-6 glioma cell line</title><secondary-title>J Biol Chem</secondary-title><alt-title>The Journal of biological chemistry</alt-title></titles><periodical><full-title>J Biol Chem</full-title><abbr-1>The Journal of biological chemistry</abbr-1></periodical><alt-periodical><full-title>J Biol Chem</full-title><abbr-1>The Journal of biological chemistry</abbr-1></alt-periodical><pages>6402-7</pages><volume>254</volume><number>14</number><edition>1979/07/25</edition><keywords><keyword>Alanine/metabolism</keyword><keyword>Aminobutyrates/metabolism</keyword><keyword>Animals</keyword><keyword>Brain/ metabolism</keyword><keyword>Carnosine/biosynthesis</keyword><keyword>Cell Line</keyword><keyword>Dipeptides/ biosynthesis</keyword><keyword>Glioma/ metabolism</keyword><keyword>Ornithine/metabolism</keyword><keyword>Peptide Biosynthesis</keyword><keyword>Rats</keyword></keywords><dates><year>1979</year><pub-dates><date>Jul 25</date></pub-dates></dates><isbn>0021-9258 (Print)&#xD;0021-9258 (Linking)</isbn><accession-num>447723</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[186]. Синтез карнозина в нейронах обнаружен не был, однако нейроны были способны поглощать карнозин из среды и метаболизировать его PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXVlcjwvQXV0aG9yPjxZZWFyPjE5ODI8L1llYXI+PFJl

Y051bT4zNDI8L1JlY051bT48RGlzcGxheVRleHQ+WzE4Ny0xOTBdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjM0MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9Incyd2Z4YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MzQyPC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYXVlciwgSy48L2F1dGhvcj48YXV0

aG9yPkhhbGxlcm1heWVyLCBLLjwvYXV0aG9yPjxhdXRob3I+U2Fsbmlrb3csIEouPC9hdXRob3I+

PGF1dGhvcj5LbGVpbmthdWYsIEguPC9hdXRob3I+PGF1dGhvcj5IYW1wcmVjaHQsIEIuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkJpb3N5bnRoZXNpcyBv

ZiBjYXJub3NpbmUgYW5kIHJlbGF0ZWQgcGVwdGlkZXMgYnkgZ2xpYWwgY2VsbHMgaW4gcHJpbWFy

eSBjdWx0dXJlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9mdWxs

LXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2FiYnIt

MT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4zNTkzLTc8L3BhZ2VzPjx2b2x1bWU+MjU3PC92

b2x1bWU+PG51bWJlcj43PC9udW1iZXI+PGVkaXRpb24+MTk4Mi8wNC8xMDwvZWRpdGlvbj48a2V5

d29yZHM+PGtleXdvcmQ+QWxhbmluZS9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1h

bHM8L2tleXdvcmQ+PGtleXdvcmQ+QW5pbWFscywgTmV3Ym9ybjwva2V5d29yZD48a2V5d29yZD5C

cmFpbi8gbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5DYXJub3NpbmUvYW5hbG9ncyAmYW1w

OyBkZXJpdmF0aXZlcy8gYmlvc3ludGhlc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNlbGxzLCBDdWx0

dXJlZDwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGVzLyBiaW9zeW50aGVzaXM8L2tleXdvcmQ+

PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TWljZTwva2V5d29yZD48a2V5d29y

ZD5OZXVyb2dsaWEvIG1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Z2FtbWEtQW1pbm9idXR5

cmljIEFjaWQvbWV0YWJvbGlzbTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTgy

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByIDEwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDAyMS05MjU4IChQcmludCkmI3hEOzAwMjEtOTI1OCAoTGlua2luZyk8L2lzYm4+PGFj

Y2Vzc2lvbi1udW0+NzA2MTUwMDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TY2h1bHo8L0F1dGhv

cj48WWVhcj4xOTg3PC9ZZWFyPjxSZWNOdW0+MzQwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJl

cj4zNDA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3Mndm

eGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjM0MDwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+U2NodWx6LCBNLjwvYXV0aG9yPjxhdXRob3I+SGFtcHJlY2h0

LCBCLjwvYXV0aG9yPjxhdXRob3I+S2xlaW5rYXVmLCBILjwvYXV0aG9yPjxhdXRob3I+QmF1ZXIs

IEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlBlcHRp

ZGUgdXB0YWtlIGJ5IGFzdHJvZ2xpYS1yaWNoIGJyYWluIGN1bHR1cmVzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkogTmV1cm9jaGVtPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFs

IG9mIG5ldXJvY2hlbWlzdHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+SiBOZXVyb2NoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5Kb3VybmFsIG9mIG5ldXJvY2hl

bWlzdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

IE5ldXJvY2hlbTwvZnVsbC10aXRsZT48YWJici0xPkpvdXJuYWwgb2YgbmV1cm9jaGVtaXN0cnk8

L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz43NDgtNTU8L3BhZ2VzPjx2b2x1bWU+NDk8

L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4xOTg3LzA5LzAxPC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BbWlubyBBY2lkcy9waGFybWFjb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+QW5pbWFsczwva2V5d29yZD48a2V5d29yZD5CcmFpbi8gY3l0b2xvZ3kvZW1icnlvbG9neS9t

ZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNhcm5vc2luZS9tZXRhYm9saXNtPC9rZXl3b3Jk

PjxrZXl3b3JkPkNlbGxzLCBDdWx0dXJlZDwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGVzL3Bo

YXJtYWNvbG9neTwva2V5d29yZD48a2V5d29yZD5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCwg

RHJ1Zzwva2V5d29yZD48a2V5d29yZD5FbmVyZ3kgTWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29y

ZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TmV1

cm9nbGlhLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRpZGVzLyBtZXRhYm9saXNt

PC9rZXl3b3JkPjxrZXl3b3JkPlByZWduYW5jeTwva2V5d29yZD48a2V5d29yZD5SYXRzPC9rZXl3

b3JkPjxrZXl3b3JkPlJhdHMsIEluYnJlZCBTdHJhaW5zPC9rZXl3b3JkPjxrZXl3b3JkPlNvZGl1

bS9tZXRhYm9saXNtPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5ODc8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDIy

LTMwNDIgKFByaW50KSYjeEQ7MDAyMi0zMDQyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4zNjEyMTIzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1

YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhvZmZtYW5uPC9BdXRob3I+PFllYXI+

MTk5NjwvWWVhcj48UmVjTnVtPjMzNTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MzM1PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idzJ3ZnhhZmU2dmE5

ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj4zMzU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPkhvZmZtYW5uLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+QmFrYXJkamlldiwg

QS48L2F1dGhvcj48YXV0aG9yPkJhdWVyLCBLLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPk1heC1QbGFuY2stSW5zdGl0dXQgZnVyIGV4cGVyaW1lbnRlbGxl

IEVuZG9rcmlub2xvZ2llLCBIYW5ub3ZlciwgR2VybWFueS48L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5DYXJub3NpbmUtc3ludGhlc2lzIGluIGN1bHR1cmVzIG9mIHJhdCBnbGlhbCBjZWxs

cyBpcyByZXN0cmljdGVkIHRvIG9saWdvZGVuZHJvY3l0ZXMgYW5kIGNhcm5vc2luZSB1cHRha2Ug

dG8gYXN0cm9jeXRlczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OZXVyb3NjaSBMZXR0PC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5OZXVyb3NjaWVuY2UgbGV0dGVyczwvYWx0LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldXJvc2NpIExldHQ8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OZXVyb3NjaWVuY2UgbGV0dGVyczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cm9zY2kgTGV0dDwvZnVsbC10aXRsZT48YWJici0xPk5l

dXJvc2NpZW5jZSBsZXR0ZXJzPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjktMzI8

L3BhZ2VzPjx2b2x1bWU+MjE1PC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGVkaXRpb24+MTk5

Ni8wOC8zMDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5

d29yZD5Bc3Ryb2N5dGVzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNhcm5vc2luZS8g

bWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5DZWxscywgQ3VsdHVyZWQvbWV0YWJvbGlzbTwv

a2V5d29yZD48a2V5d29yZD5OZXVyb2dsaWEvIG1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+

T2xpZ29kZW5kcm9nbGlhLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlJhdHM8L2tleXdv

cmQ+PGtleXdvcmQ+UmF0cywgU3ByYWd1ZS1EYXdsZXk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MTk5NjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZyAzMDwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjAzMDQtMzk0MCAoUHJpbnQpJiN4RDswMzA0LTM5NDAgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjg4ODA3NDY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91

cmxzPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

QmlmZm88L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxSZWNOdW0+MTA2PC9SZWNOdW0+PHJlY29y

ZD48cmVjLW51bWJlcj4xMDY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjEwNjwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmlmZm8sIFMuPC9hdXRob3I+PGF1dGhv

cj5HcmlsbG8sIE0uPC9hdXRob3I+PGF1dGhvcj5NYXJnb2xpcywgRi4gTC48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE5ldXJvc2Np

ZW5jZXMsIFJvY2hlIEluc3RpdHV0ZSBvZiBNb2xlY3VsYXIgQmlvbG9neSwgUm9jaGUgUmVzZWFy

Y2ggQ2VudGVyLCBOdXRsZXksIE5KIDA3MTEwLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkNlbGx1bGFyIGxvY2FsaXphdGlvbiBvZiBjYXJub3NpbmUtbGlrZSBhbmQgYW5zZXJpbmUtbGlr

ZSBpbW11bm9yZWFjdGl2aXRpZXMgaW4gcm9kZW50IGFuZCBhdmlhbiBjZW50cmFsIG5lcnZvdXMg

c3lzdGVtPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldXJvc2NpZW5jZTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+TmV1cm9zY2llbmNlPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+TmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+TmV1cm9zY2ll

bmNlPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXVy

b3NjaWVuY2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5OZXVyb3NjaWVuY2U8L2FiYnItMT48L2FsdC1w

ZXJpb2RpY2FsPjxwYWdlcz42MzctNTE8L3BhZ2VzPjx2b2x1bWU+MzU8L3ZvbHVtZT48bnVtYmVy

PjM8L251bWJlcj48ZWRpdGlvbj4xOTkwLzAxLzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29y

ZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHMsIE5ld2Jvcm48L2tleXdvcmQ+PGtl

eXdvcmQ+QW5zZXJpbmUvIGFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluLyBjeXRvbG9n

eTwva2V5d29yZD48a2V5d29yZD5DYXJub3NpbmUvIGFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3Jk

PkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkNvbHVtYmlkYWU8L2tleXdvcmQ+PGtleXdvcmQ+

RGlwZXB0aWRlcy8gYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5lIFNlcmE8L2tleXdv

cmQ+PGtleXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWlj

ZTwva2V5d29yZD48a2V5d29yZD5PbGZhY3RvcnkgQnVsYi8gY3l0b2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+T2xmYWN0b3J5IE11Y29zYS8gY3l0b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+T3JnYW4g

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+UmF0czwva2V5d29yZD48a2V5d29yZD5TcGVj

aWVzIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5OTA8L3ll

YXI+PC9kYXRlcz48aXNibj4wMzA2LTQ1MjIgKFByaW50KSYjeEQ7MDMwNi00NTIyIChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4yMTk5ODQ0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJs

cz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYXVlcjwvQXV0aG9yPjxZZWFyPjE5ODI8L1llYXI+PFJl

Y051bT4zNDI8L1JlY051bT48RGlzcGxheVRleHQ+WzE4Ny0xOTBdPC9EaXNwbGF5VGV4dD48cmVj

b3JkPjxyZWMtbnVtYmVyPjM0MjwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJF

TiIgZGItaWQ9Incyd2Z4YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MzQyPC9rZXk+

PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10

eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYXVlciwgSy48L2F1dGhvcj48YXV0

aG9yPkhhbGxlcm1heWVyLCBLLjwvYXV0aG9yPjxhdXRob3I+U2Fsbmlrb3csIEouPC9hdXRob3I+

PGF1dGhvcj5LbGVpbmthdWYsIEguPC9hdXRob3I+PGF1dGhvcj5IYW1wcmVjaHQsIEIuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPkJpb3N5bnRoZXNpcyBv

ZiBjYXJub3NpbmUgYW5kIHJlbGF0ZWQgcGVwdGlkZXMgYnkgZ2xpYWwgY2VsbHMgaW4gcHJpbWFy

eSBjdWx0dXJlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9mdWxs

LXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2FiYnIt

MT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4zNTkzLTc8L3BhZ2VzPjx2b2x1bWU+MjU3PC92

b2x1bWU+PG51bWJlcj43PC9udW1iZXI+PGVkaXRpb24+MTk4Mi8wNC8xMDwvZWRpdGlvbj48a2V5

d29yZHM+PGtleXdvcmQ+QWxhbmluZS9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1h

bHM8L2tleXdvcmQ+PGtleXdvcmQ+QW5pbWFscywgTmV3Ym9ybjwva2V5d29yZD48a2V5d29yZD5C

cmFpbi8gbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5DYXJub3NpbmUvYW5hbG9ncyAmYW1w

OyBkZXJpdmF0aXZlcy8gYmlvc3ludGhlc2lzPC9rZXl3b3JkPjxrZXl3b3JkPkNlbGxzLCBDdWx0

dXJlZDwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGVzLyBiaW9zeW50aGVzaXM8L2tleXdvcmQ+

PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TWljZTwva2V5d29yZD48a2V5d29y

ZD5OZXVyb2dsaWEvIG1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Z2FtbWEtQW1pbm9idXR5

cmljIEFjaWQvbWV0YWJvbGlzbTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTgy

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXByIDEwPC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDAyMS05MjU4IChQcmludCkmI3hEOzAwMjEtOTI1OCAoTGlua2luZyk8L2lzYm4+PGFj

Y2Vzc2lvbi1udW0+NzA2MTUwMDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5TY2h1bHo8L0F1dGhv

cj48WWVhcj4xOTg3PC9ZZWFyPjxSZWNOdW0+MzQwPC9SZWNOdW0+PHJlY29yZD48cmVjLW51bWJl

cj4zNDA8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3Mndm

eGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjM0MDwva2V5PjwvZm9yZWlnbi1rZXlz

PjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29udHJpYnV0

b3JzPjxhdXRob3JzPjxhdXRob3I+U2NodWx6LCBNLjwvYXV0aG9yPjxhdXRob3I+SGFtcHJlY2h0

LCBCLjwvYXV0aG9yPjxhdXRob3I+S2xlaW5rYXVmLCBILjwvYXV0aG9yPjxhdXRob3I+QmF1ZXIs

IEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlBlcHRp

ZGUgdXB0YWtlIGJ5IGFzdHJvZ2xpYS1yaWNoIGJyYWluIGN1bHR1cmVzPC90aXRsZT48c2Vjb25k

YXJ5LXRpdGxlPkogTmV1cm9jaGVtPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5Kb3VybmFs

IG9mIG5ldXJvY2hlbWlzdHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwt

dGl0bGU+SiBOZXVyb2NoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5Kb3VybmFsIG9mIG5ldXJvY2hl

bWlzdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

IE5ldXJvY2hlbTwvZnVsbC10aXRsZT48YWJici0xPkpvdXJuYWwgb2YgbmV1cm9jaGVtaXN0cnk8

L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz43NDgtNTU8L3BhZ2VzPjx2b2x1bWU+NDk8

L3ZvbHVtZT48bnVtYmVyPjM8L251bWJlcj48ZWRpdGlvbj4xOTg3LzA5LzAxPC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BbWlubyBBY2lkcy9waGFybWFjb2xvZ3k8L2tleXdvcmQ+PGtleXdv

cmQ+QW5pbWFsczwva2V5d29yZD48a2V5d29yZD5CcmFpbi8gY3l0b2xvZ3kvZW1icnlvbG9neS9t

ZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNhcm5vc2luZS9tZXRhYm9saXNtPC9rZXl3b3Jk

PjxrZXl3b3JkPkNlbGxzLCBDdWx0dXJlZDwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGVzL3Bo

YXJtYWNvbG9neTwva2V5d29yZD48a2V5d29yZD5Eb3NlLVJlc3BvbnNlIFJlbGF0aW9uc2hpcCwg

RHJ1Zzwva2V5d29yZD48a2V5d29yZD5FbmVyZ3kgTWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29y

ZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TmV1

cm9nbGlhLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRpZGVzLyBtZXRhYm9saXNt

PC9rZXl3b3JkPjxrZXl3b3JkPlByZWduYW5jeTwva2V5d29yZD48a2V5d29yZD5SYXRzPC9rZXl3

b3JkPjxrZXl3b3JkPlJhdHMsIEluYnJlZCBTdHJhaW5zPC9rZXl3b3JkPjxrZXl3b3JkPlNvZGl1

bS9tZXRhYm9saXNtPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5ODc8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5TZXA8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDIy

LTMwNDIgKFByaW50KSYjeEQ7MDAyMi0zMDQyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51

bT4zNjEyMTIzPC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXBy

b3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1

YWdlPjwvcmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkhvZmZtYW5uPC9BdXRob3I+PFllYXI+

MTk5NjwvWWVhcj48UmVjTnVtPjMzNTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MzM1PC9y

ZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idzJ3ZnhhZmU2dmE5

ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj4zMzU8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5

cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0

aG9ycz48YXV0aG9yPkhvZmZtYW5uLCBBLiBNLjwvYXV0aG9yPjxhdXRob3I+QmFrYXJkamlldiwg

QS48L2F1dGhvcj48YXV0aG9yPkJhdWVyLCBLLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRyaWJ1

dG9ycz48YXV0aC1hZGRyZXNzPk1heC1QbGFuY2stSW5zdGl0dXQgZnVyIGV4cGVyaW1lbnRlbGxl

IEVuZG9rcmlub2xvZ2llLCBIYW5ub3ZlciwgR2VybWFueS48L2F1dGgtYWRkcmVzcz48dGl0bGVz

Pjx0aXRsZT5DYXJub3NpbmUtc3ludGhlc2lzIGluIGN1bHR1cmVzIG9mIHJhdCBnbGlhbCBjZWxs

cyBpcyByZXN0cmljdGVkIHRvIG9saWdvZGVuZHJvY3l0ZXMgYW5kIGNhcm5vc2luZSB1cHRha2Ug

dG8gYXN0cm9jeXRlczwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5OZXVyb3NjaSBMZXR0PC9zZWNv

bmRhcnktdGl0bGU+PGFsdC10aXRsZT5OZXVyb3NjaWVuY2UgbGV0dGVyczwvYWx0LXRpdGxlPjwv

dGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPk5ldXJvc2NpIExldHQ8L2Z1bGwtdGl0bGU+

PGFiYnItMT5OZXVyb3NjaWVuY2UgbGV0dGVyczwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+TmV1cm9zY2kgTGV0dDwvZnVsbC10aXRsZT48YWJici0xPk5l

dXJvc2NpZW5jZSBsZXR0ZXJzPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjktMzI8

L3BhZ2VzPjx2b2x1bWU+MjE1PC92b2x1bWU+PG51bWJlcj4xPC9udW1iZXI+PGVkaXRpb24+MTk5

Ni8wOC8zMDwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5

d29yZD5Bc3Ryb2N5dGVzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNhcm5vc2luZS8g

bWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5DZWxscywgQ3VsdHVyZWQvbWV0YWJvbGlzbTwv

a2V5d29yZD48a2V5d29yZD5OZXVyb2dsaWEvIG1ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+

T2xpZ29kZW5kcm9nbGlhLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlJhdHM8L2tleXdv

cmQ+PGtleXdvcmQ+UmF0cywgU3ByYWd1ZS1EYXdsZXk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0

ZXM+PHllYXI+MTk5NjwveWVhcj48cHViLWRhdGVzPjxkYXRlPkF1ZyAzMDwvZGF0ZT48L3B1Yi1k

YXRlcz48L2RhdGVzPjxpc2JuPjAzMDQtMzk0MCAoUHJpbnQpJiN4RDswMzA0LTM5NDAgKExpbmtp

bmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjg4ODA3NDY8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91

cmxzPjxyZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlk

ZXI+PGxhbmd1YWdlPmVuZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjxDaXRlPjxBdXRob3I+

QmlmZm88L0F1dGhvcj48WWVhcj4xOTkwPC9ZZWFyPjxSZWNOdW0+MTA2PC9SZWNOdW0+PHJlY29y

ZD48cmVjLW51bWJlcj4xMDY8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjEwNjwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+QmlmZm8sIFMuPC9hdXRob3I+PGF1dGhv

cj5HcmlsbG8sIE0uPC9hdXRob3I+PGF1dGhvcj5NYXJnb2xpcywgRi4gTC48L2F1dGhvcj48L2F1

dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIE5ldXJvc2Np

ZW5jZXMsIFJvY2hlIEluc3RpdHV0ZSBvZiBNb2xlY3VsYXIgQmlvbG9neSwgUm9jaGUgUmVzZWFy

Y2ggQ2VudGVyLCBOdXRsZXksIE5KIDA3MTEwLjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRpdGxl

PkNlbGx1bGFyIGxvY2FsaXphdGlvbiBvZiBjYXJub3NpbmUtbGlrZSBhbmQgYW5zZXJpbmUtbGlr

ZSBpbW11bm9yZWFjdGl2aXRpZXMgaW4gcm9kZW50IGFuZCBhdmlhbiBjZW50cmFsIG5lcnZvdXMg

c3lzdGVtPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPk5ldXJvc2NpZW5jZTwvc2Vjb25kYXJ5LXRp

dGxlPjxhbHQtdGl0bGU+TmV1cm9zY2llbmNlPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGlj

YWw+PGZ1bGwtdGl0bGU+TmV1cm9zY2llbmNlPC9mdWxsLXRpdGxlPjxhYmJyLTE+TmV1cm9zY2ll

bmNlPC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5OZXVy

b3NjaWVuY2U8L2Z1bGwtdGl0bGU+PGFiYnItMT5OZXVyb3NjaWVuY2U8L2FiYnItMT48L2FsdC1w

ZXJpb2RpY2FsPjxwYWdlcz42MzctNTE8L3BhZ2VzPjx2b2x1bWU+MzU8L3ZvbHVtZT48bnVtYmVy

PjM8L251bWJlcj48ZWRpdGlvbj4xOTkwLzAxLzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29y

ZD5BbmltYWxzPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHMsIE5ld2Jvcm48L2tleXdvcmQ+PGtl

eXdvcmQ+QW5zZXJpbmUvIGFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluLyBjeXRvbG9n

eTwva2V5d29yZD48a2V5d29yZD5DYXJub3NpbmUvIGFuYWx5c2lzPC9rZXl3b3JkPjxrZXl3b3Jk

PkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkNvbHVtYmlkYWU8L2tleXdvcmQ+PGtleXdvcmQ+

RGlwZXB0aWRlcy8gYW5hbHlzaXM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5lIFNlcmE8L2tleXdv

cmQ+PGtleXdvcmQ+SW1tdW5vZW56eW1lIFRlY2huaXF1ZXM8L2tleXdvcmQ+PGtleXdvcmQ+TWlj

ZTwva2V5d29yZD48a2V5d29yZD5PbGZhY3RvcnkgQnVsYi8gY3l0b2xvZ3k8L2tleXdvcmQ+PGtl

eXdvcmQ+T2xmYWN0b3J5IE11Y29zYS8gY3l0b2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+T3JnYW4g

U3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdvcmQ+UmF0czwva2V5d29yZD48a2V5d29yZD5TcGVj

aWVzIFNwZWNpZmljaXR5PC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5OTA8L3ll

YXI+PC9kYXRlcz48aXNibj4wMzA2LTQ1MjIgKFByaW50KSYjeEQ7MDMwNi00NTIyIChMaW5raW5n

KTwvaXNibj48YWNjZXNzaW9uLW51bT4yMTk5ODQ0PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJs

cz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

PjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [187-190]. Интересно отметить, что усиление синтеза карнозина сопровождалось дифференцировкой глиальных клеток, что оценивалось по усилению иммуноокрашивания антителами к маркерам дифференциации ADDIN EN.CITE <EndNote><Cite><Author>Hoffmann</Author><Year>1996</Year><RecNum>335</RecNum><DisplayText>[189]</DisplayText><record><rec-number>335</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">335</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Hoffmann, A. M.</author><author>Bakardjiev, A.</author><author>Bauer, K.</author></authors></contributors><auth-address>Max-Planck-Institut fur experimentelle Endokrinologie, Hannover, Germany.</auth-address><titles><title>Carnosine-synthesis in cultures of rat glial cells is restricted to oligodendrocytes and carnosine uptake to astrocytes</title><secondary-title>Neurosci Lett</secondary-title><alt-title>Neuroscience letters</alt-title></titles><periodical><full-title>Neurosci Lett</full-title><abbr-1>Neuroscience letters</abbr-1></periodical><alt-periodical><full-title>Neurosci Lett</full-title><abbr-1>Neuroscience letters</abbr-1></alt-periodical><pages>29-32</pages><volume>215</volume><number>1</number><edition>1996/08/30</edition><keywords><keyword>Animals</keyword><keyword>Astrocytes/ metabolism</keyword><keyword>Carnosine/ metabolism</keyword><keyword>Cells, Cultured/metabolism</keyword><keyword>Neuroglia/ metabolism</keyword><keyword>Oligodendroglia/ metabolism</keyword><keyword>Rats</keyword><keyword>Rats, Sprague-Dawley</keyword></keywords><dates><year>1996</year><pub-dates><date>Aug 30</date></pub-dates></dates><isbn>0304-3940 (Print)&#xD;0304-3940 (Linking)</isbn><accession-num>8880746</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[189]. Сходный эффект наблюдали при обработке скелетных мышц новорожденных цыплят. Усиление синтеза карнозина замедляло скорость деления клеток и способствовало превращению миобластов в миотубулы PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWthcmRqaWV2PC9BdXRob3I+PFllYXI+MTk5NDwvWWVh

cj48UmVjTnVtPjMzNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTkxLCAxOTJdPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjMzNzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9Incyd2Z4YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MzM3

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYWthcmRqaWV2LCBBLjwv

YXV0aG9yPjxhdXRob3I+QmF1ZXIsIEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+TWF4LVBsYW5jay1JbnN0aXR1dCBmdXIgZXhwZXJpbWVudGVsbGUgRW5k

b2tyaW5vbG9naWUsIEhhbm5vdmVyLCBHZXJtYW55LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPlRyYW5zcG9ydCBvZiBiZXRhLWFsYW5pbmUgYW5kIGJpb3N5bnRoZXNpcyBvZiBjYXJub3Np

bmUgYnkgc2tlbGV0YWwgbXVzY2xlIGNlbGxzIGluIHByaW1hcnkgY3VsdHVyZTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5FdXIgSiBCaW9jaGVtPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5F

dXJvcGVhbiBqb3VybmFsIG9mIGJpb2NoZW1pc3RyeSAvIEZFQlM8L2FsdC10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXIgSiBCaW9jaGVtPC9mdWxsLXRpdGxlPjxhYmJy

LTE+RXVyb3BlYW4gam91cm5hbCBvZiBiaW9jaGVtaXN0cnkgLyBGRUJTPC9hYmJyLTE+PC9wZXJp

b2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXIgSiBCaW9jaGVtPC9mdWxsLXRp

dGxlPjxhYmJyLTE+RXVyb3BlYW4gam91cm5hbCBvZiBiaW9jaGVtaXN0cnkgLyBGRUJTPC9hYmJy

LTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjE3LTIzPC9wYWdlcz48dm9sdW1lPjIyNTwvdm9s

dW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjE5OTQvMTAvMTU8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+QmlvbG9naWNhbCBUcmFuc3Bv

cnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9zaW5lLyBiaW9zeW50aGVzaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+Q2VsbCBEaWZmZXJlbnRpYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBEaXZpc2lv

bjwva2V5d29yZD48a2V5d29yZD5DZWxscywgQ3VsdHVyZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hp

Y2sgRW1icnlvPC9rZXl3b3JkPjxrZXl3b3JkPkNyZWF0aW5lIEtpbmFzZS9tZXRhYm9saXNtPC9r

ZXl3b3JkPjxrZXl3b3JkPkROQS9iaW9zeW50aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+SW9uIFRy

YW5zcG9ydDwva2V5d29yZD48a2V5d29yZD5LaW5ldGljczwva2V5d29yZD48a2V5d29yZD5NdXNj

bGUsIFNrZWxldGFsL2N5dG9sb2d5LyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPmJldGEt

QWxhbmluZS8gbWV0YWJvbGlzbTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk0

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0IDE1PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDAxNC0yOTU2IChQcmludCkmI3hEOzAwMTQtMjk1NiAoTGlua2luZyk8L2lzYm4+PGFj

Y2Vzc2lvbi1udW0+Nzk1NzE3NjwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5CYXVlcjwvQXV0aG9y

PjxZZWFyPjE5OTQ8L1llYXI+PFJlY051bT4zMzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy

PjMzODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9Incyd2Z4

YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MzM4PC9rZXk+PC9mb3JlaWduLWtleXM+

PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv

cnM+PGF1dGhvcnM+PGF1dGhvcj5CYXVlciwgSy48L2F1dGhvcj48YXV0aG9yPlNjaHVseiwgTS48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NYXgtUGxhbmNr

LUluc3RpdHV0IGZ1ciBleHBlcmltZW50ZWxsZSBFbmRva3Jpbm9sb2dpZSwgSGFubm92ZXIsIEdl

cm1hbnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Qmlvc3ludGhlc2lzIG9mIGNhcm5v

c2luZSBhbmQgcmVsYXRlZCBwZXB0aWRlcyBieSBza2VsZXRhbCBtdXNjbGUgY2VsbHMgaW4gcHJp

bWFyeSBjdWx0dXJlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBKIEJpb2NoZW08L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9wZWFuIGpvdXJuYWwgb2YgYmlvY2hlbWlzdHJ5IC8g

RkVCUzwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1ciBKIEJp

b2NoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXJvcGVhbiBqb3VybmFsIG9mIGJpb2NoZW1pc3Ry

eSAvIEZFQlM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkV1ciBKIEJpb2NoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXJvcGVhbiBqb3VybmFsIG9mIGJp

b2NoZW1pc3RyeSAvIEZFQlM8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40My03PC9w

YWdlcz48dm9sdW1lPjIxOTwvdm9sdW1lPjxudW1iZXI+MS0yPC9udW1iZXI+PGVkaXRpb24+MTk5

NC8wMS8xNTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWxhbmluZS9tZXRhYm9saXNtPC9r

ZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+QmlvbG9naWNhbCBUcmFu

c3BvcnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9zaW5lLyBiaW9zeW50aGVzaXMvaXNvbGF0aW9u

ICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5DZWxsIERpZmZlcmVudGlhdGlv

bjwva2V5d29yZD48a2V5d29yZD5DZWxscywgQ3VsdHVyZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hp

Y2sgRW1icnlvPC9rZXl3b3JkPjxrZXl3b3JkPkNocm9tYXRvZ3JhcGh5LCBJb24gRXhjaGFuZ2U8

L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TXVzY2xlcy9jeXRv

bG9neS8gbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5QZXB0aWRlIEJpb3N5bnRoZXNpczwv

a2V5d29yZD48a2V5d29yZD5QZXB0aWRlcy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPlJhZGlvaXNvdG9wZSBEaWx1dGlvbiBUZWNobmlxdWU8L2tleXdvcmQ+

PGtleXdvcmQ+VHJpdGl1bTwva2V5d29yZD48a2V5d29yZD5nYW1tYS1BbWlub2J1dHlyaWMgQWNp

ZC9tZXRhYm9saXNtPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5OTQ8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5KYW4gMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4w

MDE0LTI5NTYgKFByaW50KSYjeEQ7MDAxNC0yOTU2IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9u

LW51bT44MzA3MDA4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xh

bmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5CYWthcmRqaWV2PC9BdXRob3I+PFllYXI+MTk5NDwvWWVh

cj48UmVjTnVtPjMzNzwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMTkxLCAxOTJdPC9EaXNwbGF5VGV4

dD48cmVjb3JkPjxyZWMtbnVtYmVyPjMzNzwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkg

YXBwPSJFTiIgZGItaWQ9Incyd2Z4YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MzM3

PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8

L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5CYWthcmRqaWV2LCBBLjwv

YXV0aG9yPjxhdXRob3I+QmF1ZXIsIEsuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3Jz

PjxhdXRoLWFkZHJlc3M+TWF4LVBsYW5jay1JbnN0aXR1dCBmdXIgZXhwZXJpbWVudGVsbGUgRW5k

b2tyaW5vbG9naWUsIEhhbm5vdmVyLCBHZXJtYW55LjwvYXV0aC1hZGRyZXNzPjx0aXRsZXM+PHRp

dGxlPlRyYW5zcG9ydCBvZiBiZXRhLWFsYW5pbmUgYW5kIGJpb3N5bnRoZXNpcyBvZiBjYXJub3Np

bmUgYnkgc2tlbGV0YWwgbXVzY2xlIGNlbGxzIGluIHByaW1hcnkgY3VsdHVyZTwvdGl0bGU+PHNl

Y29uZGFyeS10aXRsZT5FdXIgSiBCaW9jaGVtPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5F

dXJvcGVhbiBqb3VybmFsIG9mIGJpb2NoZW1pc3RyeSAvIEZFQlM8L2FsdC10aXRsZT48L3RpdGxl

cz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXIgSiBCaW9jaGVtPC9mdWxsLXRpdGxlPjxhYmJy

LTE+RXVyb3BlYW4gam91cm5hbCBvZiBiaW9jaGVtaXN0cnkgLyBGRUJTPC9hYmJyLTE+PC9wZXJp

b2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5FdXIgSiBCaW9jaGVtPC9mdWxsLXRp

dGxlPjxhYmJyLTE+RXVyb3BlYW4gam91cm5hbCBvZiBiaW9jaGVtaXN0cnkgLyBGRUJTPC9hYmJy

LTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjE3LTIzPC9wYWdlcz48dm9sdW1lPjIyNTwvdm9s

dW1lPjxudW1iZXI+MjwvbnVtYmVyPjxlZGl0aW9uPjE5OTQvMTAvMTU8L2VkaXRpb24+PGtleXdv

cmRzPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+QmlvbG9naWNhbCBUcmFuc3Bv

cnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9zaW5lLyBiaW9zeW50aGVzaXM8L2tleXdvcmQ+PGtl

eXdvcmQ+Q2VsbCBEaWZmZXJlbnRpYXRpb248L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBEaXZpc2lv

bjwva2V5d29yZD48a2V5d29yZD5DZWxscywgQ3VsdHVyZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hp

Y2sgRW1icnlvPC9rZXl3b3JkPjxrZXl3b3JkPkNyZWF0aW5lIEtpbmFzZS9tZXRhYm9saXNtPC9r

ZXl3b3JkPjxrZXl3b3JkPkROQS9iaW9zeW50aGVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+SW9uIFRy

YW5zcG9ydDwva2V5d29yZD48a2V5d29yZD5LaW5ldGljczwva2V5d29yZD48a2V5d29yZD5NdXNj

bGUsIFNrZWxldGFsL2N5dG9sb2d5LyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPmJldGEt

QWxhbmluZS8gbWV0YWJvbGlzbTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4xOTk0

PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+T2N0IDE1PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+

PGlzYm4+MDAxNC0yOTU2IChQcmludCkmI3hEOzAwMTQtMjk1NiAoTGlua2luZyk8L2lzYm4+PGFj

Y2Vzc2lvbi1udW0+Nzk1NzE3NjwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJlbW90ZS1k

YXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+

ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1dGhvcj5CYXVlcjwvQXV0aG9y

PjxZZWFyPjE5OTQ8L1llYXI+PFJlY051bT4zMzg8L1JlY051bT48cmVjb3JkPjxyZWMtbnVtYmVy

PjMzODwvcmVjLW51bWJlcj48Zm9yZWlnbi1rZXlzPjxrZXkgYXBwPSJFTiIgZGItaWQ9Incyd2Z4

YWZlNnZhOXo1ZWV2Mmw1NWFhOHN4c2E1OTllZXYycyI+MzM4PC9rZXk+PC9mb3JlaWduLWtleXM+

PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRv

cnM+PGF1dGhvcnM+PGF1dGhvcj5CYXVlciwgSy48L2F1dGhvcj48YXV0aG9yPlNjaHVseiwgTS48

L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5NYXgtUGxhbmNr

LUluc3RpdHV0IGZ1ciBleHBlcmltZW50ZWxsZSBFbmRva3Jpbm9sb2dpZSwgSGFubm92ZXIsIEdl

cm1hbnkuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+Qmlvc3ludGhlc2lzIG9mIGNhcm5v

c2luZSBhbmQgcmVsYXRlZCBwZXB0aWRlcyBieSBza2VsZXRhbCBtdXNjbGUgY2VsbHMgaW4gcHJp

bWFyeSBjdWx0dXJlPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkV1ciBKIEJpb2NoZW08L3NlY29u

ZGFyeS10aXRsZT48YWx0LXRpdGxlPkV1cm9wZWFuIGpvdXJuYWwgb2YgYmlvY2hlbWlzdHJ5IC8g

RkVCUzwvYWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkV1ciBKIEJp

b2NoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXJvcGVhbiBqb3VybmFsIG9mIGJpb2NoZW1pc3Ry

eSAvIEZFQlM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxl

PkV1ciBKIEJpb2NoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5FdXJvcGVhbiBqb3VybmFsIG9mIGJp

b2NoZW1pc3RyeSAvIEZFQlM8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz40My03PC9w

YWdlcz48dm9sdW1lPjIxOTwvdm9sdW1lPjxudW1iZXI+MS0yPC9udW1iZXI+PGVkaXRpb24+MTk5

NC8wMS8xNTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWxhbmluZS9tZXRhYm9saXNtPC9r

ZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+QmlvbG9naWNhbCBUcmFu

c3BvcnQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9zaW5lLyBiaW9zeW50aGVzaXMvaXNvbGF0aW9u

ICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5DZWxsIERpZmZlcmVudGlhdGlv

bjwva2V5d29yZD48a2V5d29yZD5DZWxscywgQ3VsdHVyZWQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hp

Y2sgRW1icnlvPC9rZXl3b3JkPjxrZXl3b3JkPkNocm9tYXRvZ3JhcGh5LCBJb24gRXhjaGFuZ2U8

L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TXVzY2xlcy9jeXRv

bG9neS8gbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5QZXB0aWRlIEJpb3N5bnRoZXNpczwv

a2V5d29yZD48a2V5d29yZD5QZXB0aWRlcy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9r

ZXl3b3JkPjxrZXl3b3JkPlJhZGlvaXNvdG9wZSBEaWx1dGlvbiBUZWNobmlxdWU8L2tleXdvcmQ+

PGtleXdvcmQ+VHJpdGl1bTwva2V5d29yZD48a2V5d29yZD5nYW1tYS1BbWlub2J1dHlyaWMgQWNp

ZC9tZXRhYm9saXNtPC9rZXl3b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5OTQ8L3llYXI+

PHB1Yi1kYXRlcz48ZGF0ZT5KYW4gMTU8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4w

MDE0LTI5NTYgKFByaW50KSYjeEQ7MDAxNC0yOTU2IChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9u

LW51bT44MzA3MDA4PC9hY2Nlc3Npb24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNl

LXByb3ZpZGVyPk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xh

bmd1YWdlPjwvcmVjb3JkPjwvQ2l0ZT48L0VuZE5vdGU+AG==

ADDIN EN.CITE.DATA [191, 192].

В организме человека существует два фермента, способных расщеплять карнозин на составные аминокислоты: сывороточная (CN1) ADDIN EN.CITE <EndNote><Cite><Author>Perry</Author><Year>1968</Year><RecNum>262</RecNum><DisplayText>[193]</DisplayText><record><rec-number>262</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">262</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Perry, T. L.</author><author>Hansen, S.</author><author>Love, D. L.</author></authors></contributors><titles><title>Serum-carnosinase deficiency in carnosinaemia</title><secondary-title>Lancet</secondary-title><alt-title>Lancet</alt-title></titles><periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1></periodical><alt-periodical><full-title>Lancet</full-title><abbr-1>Lancet</abbr-1></alt-periodical><pages>1229-30</pages><volume>1</volume><number>7554</number><edition>1968/06/08</edition><keywords><keyword>Adult</keyword><keyword>Child, Preschool</keyword><keyword>Diet</keyword><keyword>Dipeptidases/ blood</keyword><keyword>Dipeptides/ blood</keyword><keyword>Female</keyword><keyword>Humans</keyword><keyword>Infant</keyword><keyword>Intellectual Disability/blood/complications</keyword><keyword>Male</keyword><keyword>Metabolism, Inborn Errors/ blood</keyword><keyword>Nervous System Diseases/blood/complications</keyword></keywords><dates><year>1968</year><pub-dates><date>Jun 8</date></pub-dates></dates><isbn>0140-6736 (Print)&#xD;0140-6736 (Linking)</isbn><accession-num>4172777</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[193] и тканевая/цитозольная (CN2) карнозиназы PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZW5uZXk8L0F1dGhvcj48WWVhcj4xOTg1PC9ZZWFyPjxS

ZWNOdW0+MjYxPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxOTQsIDE5NV08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjYxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj4yNjE8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxlbm5leSwgSi4gRi48L2F1dGhv

cj48YXV0aG9yPlBlcHBlcnMsIFMuIEMuPC9hdXRob3I+PGF1dGhvcj5LdWNlcmEtT3JhbGxvLCBD

LiBNLjwvYXV0aG9yPjxhdXRob3I+R2VvcmdlLCBSLiBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5DaGFyYWN0ZXJpemF0aW9uIG9mIGh1bWFuIHRpc3N1

ZSBjYXJub3NpbmFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CaW9jaGVtIEo8L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPlRoZSBCaW9jaGVtaWNhbCBqb3VybmFsPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmlvY2hlbSBKPC9mdWxsLXRpdGxlPjxhYmJy

LTE+VGhlIEJpb2NoZW1pY2FsIGpvdXJuYWw8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkJpb2NoZW0gSjwvZnVsbC10aXRsZT48YWJici0xPlRoZSBCaW9j

aGVtaWNhbCBqb3VybmFsPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjUzLTYwPC9w

YWdlcz48dm9sdW1lPjIyODwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjE5ODUv

MDYvMTU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNhdGlvbnMsIERpdmFsZW50L3BoYXJt

YWNvbG9neTwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGFzZXMvYW50YWdvbmlzdHMgJmFtcDsg

aW5oaWJpdG9ycy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uLyBtZXRhYm9saXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkRpdGhpb3RocmVpdG9sL3BoYXJtYWNvbG9neTwva2V5d29yZD48a2V5d29y

ZD5FbGVjdHJvcGhvcmVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+RW56eW1lIEFjdGl2YXRpb24vZHJ1

ZyBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5IeWRy

b2dlbi1Jb24gQ29uY2VudHJhdGlvbjwva2V5d29yZD48a2V5d29yZD5Jc29lbGVjdHJpYyBQb2lu

dDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+VGlzc3VlIERpc3RyaWJ1dGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4x

OTg1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuIDE1PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0

ZXM+PGlzYm4+MDI2NC02MDIxIChQcmludCkmI3hEOzAyNjQtNjAyMSAoTGlua2luZyk8L2lzYm4+

PGFjY2Vzc2lvbi1udW0+NDAyNjgwMTwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3Rv

bTI+UE1DMTE0NTAzNDwvY3VzdG9tMj48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkxlbm5leTwvQXV0aG9yPjxZZWFyPjE5ODI8L1llYXI+PFJlY051

bT44OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+ODk8L3JlYy1udW1iZXI+PGZvcmVpZ24t

a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5

ZWV2MnMiPjg5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MZW5uZXks

IEouIEYuPC9hdXRob3I+PGF1dGhvcj5HZW9yZ2UsIFIuIFAuPC9hdXRob3I+PGF1dGhvcj5XZWlz

cywgQS4gTS48L2F1dGhvcj48YXV0aG9yPkt1Y2VyYSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPkNo

YW4sIFAuIFcuPC9hdXRob3I+PGF1dGhvcj5SaW56bGVyLCBHLiBTLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5IdW1hbiBzZXJ1bSBjYXJub3NpbmFzZTog

Y2hhcmFjdGVyaXphdGlvbiwgZGlzdGluY3Rpb24gZnJvbSBjZWxsdWxhciBjYXJub3NpbmFzZSwg

YW5kIGFjdGl2YXRpb24gYnkgY2FkbWl1bTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIENo

aW0gQWN0YTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYSBjaGltaWNhIGFjdGE7

IGludGVybmF0aW9uYWwgam91cm5hbCBvZiBjbGluaWNhbCBjaGVtaXN0cnk8L2FsdC10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIENoaW0gQWN0YTwvZnVsbC10aXRs

ZT48YWJici0xPkNsaW5pY2EgY2hpbWljYSBhY3RhOyBpbnRlcm5hdGlvbmFsIGpvdXJuYWwgb2Yg

Y2xpbmljYWwgY2hlbWlzdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5DbGluIENoaW0gQWN0YTwvZnVsbC10aXRsZT48YWJici0xPkNsaW5pY2EgY2hp

bWljYSBhY3RhOyBpbnRlcm5hdGlvbmFsIGpvdXJuYWwgb2YgY2xpbmljYWwgY2hlbWlzdHJ5PC9h

YmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjIxLTMxPC9wYWdlcz48dm9sdW1lPjEyMzwv

dm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjE5ODIvMDgvMTg8L2VkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdv

cmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2luZzwva2V5d29yZD48a2V5d29y

ZD5DYWRtaXVtLyBibG9vZDwva2V5d29yZD48a2V5d29yZD5DYXJub3NpbmUvYW5hbG9ncyAmYW1w

OyBkZXJpdmF0aXZlcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3Jk

PjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+RGlwZXB0aWRhc2Vz

LyBibG9vZDwva2V5d29yZD48a2V5d29yZD5Fbnp5bWUgQWN0aXZhdGlvbi9kcnVnIGVmZmVjdHM8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29y

ZD48a2V5d29yZD5Jc29lbGVjdHJpYyBQb2ludDwva2V5d29yZD48a2V5d29yZD5Jc29lbnp5bWVz

LyBibG9vZDwva2V5d29yZD48a2V5d29yZD5LaW5ldGljczwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Nb2xlY3VsYXIgV2VpZ2h0PC9rZXl3b3JkPjxrZXl3

b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVh

cj4xOTgyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDE4PC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MDAwOS04OTgxIChQcmludCkmI3hEOzAwMDktODk4MSAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+NzExNjY0NDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5MZW5uZXk8L0F1dGhvcj48WWVhcj4xOTg1PC9ZZWFyPjxS

ZWNOdW0+MjYxPC9SZWNOdW0+PERpc3BsYXlUZXh0PlsxOTQsIDE5NV08L0Rpc3BsYXlUZXh0Pjxy

ZWNvcmQ+PHJlYy1udW1iZXI+MjYxPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9

IkVOIiBkYi1pZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj4yNjE8L2tl

eT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4xNzwvcmVm

LXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkxlbm5leSwgSi4gRi48L2F1dGhv

cj48YXV0aG9yPlBlcHBlcnMsIFMuIEMuPC9hdXRob3I+PGF1dGhvcj5LdWNlcmEtT3JhbGxvLCBD

LiBNLjwvYXV0aG9yPjxhdXRob3I+R2VvcmdlLCBSLiBQLjwvYXV0aG9yPjwvYXV0aG9ycz48L2Nv

bnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5DaGFyYWN0ZXJpemF0aW9uIG9mIGh1bWFuIHRpc3N1

ZSBjYXJub3NpbmFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CaW9jaGVtIEo8L3NlY29uZGFy

eS10aXRsZT48YWx0LXRpdGxlPlRoZSBCaW9jaGVtaWNhbCBqb3VybmFsPC9hbHQtdGl0bGU+PC90

aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QmlvY2hlbSBKPC9mdWxsLXRpdGxlPjxhYmJy

LTE+VGhlIEJpb2NoZW1pY2FsIGpvdXJuYWw8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJp

b2RpY2FsPjxmdWxsLXRpdGxlPkJpb2NoZW0gSjwvZnVsbC10aXRsZT48YWJici0xPlRoZSBCaW9j

aGVtaWNhbCBqb3VybmFsPC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjUzLTYwPC9w

YWdlcz48dm9sdW1lPjIyODwvdm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjE5ODUv

MDYvMTU8L2VkaXRpb24+PGtleXdvcmRzPjxrZXl3b3JkPkNhdGlvbnMsIERpdmFsZW50L3BoYXJt

YWNvbG9neTwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGFzZXMvYW50YWdvbmlzdHMgJmFtcDsg

aW5oaWJpdG9ycy9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uLyBtZXRhYm9saXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkRpdGhpb3RocmVpdG9sL3BoYXJtYWNvbG9neTwva2V5d29yZD48a2V5d29y

ZD5FbGVjdHJvcGhvcmVzaXM8L2tleXdvcmQ+PGtleXdvcmQ+RW56eW1lIEFjdGl2YXRpb24vZHJ1

ZyBlZmZlY3RzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5IeWRy

b2dlbi1Jb24gQ29uY2VudHJhdGlvbjwva2V5d29yZD48a2V5d29yZD5Jc29lbGVjdHJpYyBQb2lu

dDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtleXdv

cmQ+VGlzc3VlIERpc3RyaWJ1dGlvbjwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVhcj4x

OTg1PC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+SnVuIDE1PC9kYXRlPjwvcHViLWRhdGVzPjwvZGF0

ZXM+PGlzYm4+MDI2NC02MDIxIChQcmludCkmI3hEOzAyNjQtNjAyMSAoTGlua2luZyk8L2lzYm4+

PGFjY2Vzc2lvbi1udW0+NDAyNjgwMTwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PGN1c3Rv

bTI+UE1DMTE0NTAzNDwvY3VzdG9tMj48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVt

b3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwv

Q2l0ZT48Q2l0ZT48QXV0aG9yPkxlbm5leTwvQXV0aG9yPjxZZWFyPjE5ODI8L1llYXI+PFJlY051

bT44OTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+ODk8L3JlYy1udW1iZXI+PGZvcmVpZ24t

a2V5cz48a2V5IGFwcD0iRU4iIGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5

ZWV2MnMiPjg5PC9rZXk+PC9mb3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0

aWNsZSI+MTc8L3JlZi10eXBlPjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5MZW5uZXks

IEouIEYuPC9hdXRob3I+PGF1dGhvcj5HZW9yZ2UsIFIuIFAuPC9hdXRob3I+PGF1dGhvcj5XZWlz

cywgQS4gTS48L2F1dGhvcj48YXV0aG9yPkt1Y2VyYSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPkNo

YW4sIFAuIFcuPC9hdXRob3I+PGF1dGhvcj5SaW56bGVyLCBHLiBTLjwvYXV0aG9yPjwvYXV0aG9y

cz48L2NvbnRyaWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5IdW1hbiBzZXJ1bSBjYXJub3NpbmFzZTog

Y2hhcmFjdGVyaXphdGlvbiwgZGlzdGluY3Rpb24gZnJvbSBjZWxsdWxhciBjYXJub3NpbmFzZSwg

YW5kIGFjdGl2YXRpb24gYnkgY2FkbWl1bTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5DbGluIENo

aW0gQWN0YTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+Q2xpbmljYSBjaGltaWNhIGFjdGE7

IGludGVybmF0aW9uYWwgam91cm5hbCBvZiBjbGluaWNhbCBjaGVtaXN0cnk8L2FsdC10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5DbGluIENoaW0gQWN0YTwvZnVsbC10aXRs

ZT48YWJici0xPkNsaW5pY2EgY2hpbWljYSBhY3RhOyBpbnRlcm5hdGlvbmFsIGpvdXJuYWwgb2Yg

Y2xpbmljYWwgY2hlbWlzdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48

ZnVsbC10aXRsZT5DbGluIENoaW0gQWN0YTwvZnVsbC10aXRsZT48YWJici0xPkNsaW5pY2EgY2hp

bWljYSBhY3RhOyBpbnRlcm5hdGlvbmFsIGpvdXJuYWwgb2YgY2xpbmljYWwgY2hlbWlzdHJ5PC9h

YmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+MjIxLTMxPC9wYWdlcz48dm9sdW1lPjEyMzwv

dm9sdW1lPjxudW1iZXI+MzwvbnVtYmVyPjxlZGl0aW9uPjE5ODIvMDgvMTg8L2VkaXRpb24+PGtl

eXdvcmRzPjxrZXl3b3JkPkFkb2xlc2NlbnQ8L2tleXdvcmQ+PGtleXdvcmQ+QWR1bHQ8L2tleXdv

cmQ+PGtleXdvcmQ+QWdlZDwva2V5d29yZD48a2V5d29yZD5BZ2luZzwva2V5d29yZD48a2V5d29y

ZD5DYWRtaXVtLyBibG9vZDwva2V5d29yZD48a2V5d29yZD5DYXJub3NpbmUvYW5hbG9ncyAmYW1w

OyBkZXJpdmF0aXZlcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkNoaWxkPC9rZXl3b3Jk

PjxrZXl3b3JkPkNoaWxkLCBQcmVzY2hvb2w8L2tleXdvcmQ+PGtleXdvcmQ+RGlwZXB0aWRhc2Vz

LyBibG9vZDwva2V5d29yZD48a2V5d29yZD5Fbnp5bWUgQWN0aXZhdGlvbi9kcnVnIGVmZmVjdHM8

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29y

ZD48a2V5d29yZD5Jc29lbGVjdHJpYyBQb2ludDwva2V5d29yZD48a2V5d29yZD5Jc29lbnp5bWVz

LyBibG9vZDwva2V5d29yZD48a2V5d29yZD5LaW5ldGljczwva2V5d29yZD48a2V5d29yZD5NaWRk

bGUgQWdlZDwva2V5d29yZD48a2V5d29yZD5Nb2xlY3VsYXIgV2VpZ2h0PC9rZXl3b3JkPjxrZXl3

b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5d29yZD48L2tleXdvcmRzPjxkYXRlcz48eWVh

cj4xOTgyPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+QXVnIDE4PC9kYXRlPjwvcHViLWRhdGVzPjwv

ZGF0ZXM+PGlzYm4+MDAwOS04OTgxIChQcmludCkmI3hEOzAwMDktODk4MSAoTGlua2luZyk8L2lz

Ym4+PGFjY2Vzc2lvbi1udW0+NzExNjY0NDwvYWNjZXNzaW9uLW51bT48dXJscz48L3VybHM+PHJl

bW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFu

Z3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [194, 195]. CN1 экспрессируется главным образом в мозге, и в меньшей степени в печени. Иммуногистохимическое исследование выявило присутствие CN1 в цитозоле пирамидальных нейронов гиппокампа, а также в больших и малых нейронах коры больших полушарий. Цитозольная фракция клеток, секретирующих CN1, не деградировала карнозин, указывая на то, что CN1 относится к секретируемым белкам и активен только после секреции PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzldPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj45OTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGV1ZmVsLCBNLjwvYXV0aG9yPjxhdXRob3I+U2F1

ZGVrLCBWLjwvYXV0aG9yPjxhdXRob3I+TGVkaWcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5CZXJu

aGFyZHQsIEEuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYXJhbmQsIFMuPC9hdXRob3I+PGF1dGhvcj5D

YXJyZWF1LCBBLjwvYXV0aG9yPjxhdXRob3I+Q2Fpcm5zLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

Q2FydGVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Q293bGV5LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+

RHV2ZXJnZXIsIEQuPC9hdXRob3I+PGF1dGhvcj5HYW56aG9ybiwgQS4gSi48L2F1dGhvcj48YXV0

aG9yPkd1ZW5ldCwgQy48L2F1dGhvcj48YXV0aG9yPkhlaW50emVsbWFubiwgQi48L2F1dGhvcj48

YXV0aG9yPkxhdWNoZXIsIFYuPC9hdXRob3I+PGF1dGhvcj5TYXV2YWdlLCBDLjwvYXV0aG9yPjxh

dXRob3I+U21pcm5vdmEsIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFeHBsb3JhdG9yeSBSZXNlYXJjaCwgU2Fub2ZpIFN5bnRo

ZWxhYm8gUmVjaGVyY2hlLCAxNiBSdWUgZCZhcG9zO0Fua2FyYSwgRi02NzA4MCBTdHJhc2JvdXJn

LCBGcmFuY2UuIG1pY2hhZWwudGV1ZmVsQHNhbm9maS1zeW50aGVsYWJvLmNvbTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlNlcXVlbmNlIGlkZW50aWZpY2F0aW9uIGFuZCBjaGFyYWN0ZXJp

emF0aW9uIG9mIGh1bWFuIGNhcm5vc2luYXNlIGFuZCBhIGNsb3NlbHkgcmVsYXRlZCBub24tc3Bl

Y2lmaWMgZGlwZXB0aWRhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBCaW9sIENoZW08L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hlbWlz

dHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9sIENo

ZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3Ry

eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9s

IENoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1p

c3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY1MjEtMzE8L3BhZ2VzPjx2b2x1

bWU+Mjc4PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwMi8xMi8xMTwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5

d29yZD5CYXNlIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluL2Vuenltb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2xvbmluZywgTW9sZWN1bGFyPC9rZXl3b3JkPjxrZXl3b3JkPkRpcGVw

dGlkYXNlcy8gY2hlbWlzdHJ5LyBnZW5ldGljcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkV4cHJlc3NlZCBTZXF1ZW5jZSBUYWdzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgVmVjdG9y

czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vaGlzdG9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TW9s

ZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YWdlbmVzaXMsIFNpdGUt

RGlyZWN0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHNldWRvbW9uYXMvZW56eW1vbG9neTwva2V5d29y

ZD48a2V5d29yZD5SZWNvbWJpbmFudCBQcm90ZWlucy9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdv

cmQ+U2VxdWVuY2UgQWxpZ25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEhvbW9sb2d5

LCBBbWlubyBBY2lkPC9rZXl3b3JkPjxrZXl3b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5

d29yZD48a2V5d29yZD5nYW1tYS1HbHV0YW15bCBIeWRyb2xhc2U8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjEtOTI1OCAoUHJpbnQpJiN4RDswMDIxLTkyNTgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyNDczNjc2PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA3NC9qYmMuTTIwOTc2NDIw

MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzldPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj45OTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGV1ZmVsLCBNLjwvYXV0aG9yPjxhdXRob3I+U2F1

ZGVrLCBWLjwvYXV0aG9yPjxhdXRob3I+TGVkaWcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5CZXJu

aGFyZHQsIEEuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYXJhbmQsIFMuPC9hdXRob3I+PGF1dGhvcj5D

YXJyZWF1LCBBLjwvYXV0aG9yPjxhdXRob3I+Q2Fpcm5zLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

Q2FydGVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Q293bGV5LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+

RHV2ZXJnZXIsIEQuPC9hdXRob3I+PGF1dGhvcj5HYW56aG9ybiwgQS4gSi48L2F1dGhvcj48YXV0

aG9yPkd1ZW5ldCwgQy48L2F1dGhvcj48YXV0aG9yPkhlaW50emVsbWFubiwgQi48L2F1dGhvcj48

YXV0aG9yPkxhdWNoZXIsIFYuPC9hdXRob3I+PGF1dGhvcj5TYXV2YWdlLCBDLjwvYXV0aG9yPjxh

dXRob3I+U21pcm5vdmEsIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFeHBsb3JhdG9yeSBSZXNlYXJjaCwgU2Fub2ZpIFN5bnRo

ZWxhYm8gUmVjaGVyY2hlLCAxNiBSdWUgZCZhcG9zO0Fua2FyYSwgRi02NzA4MCBTdHJhc2JvdXJn

LCBGcmFuY2UuIG1pY2hhZWwudGV1ZmVsQHNhbm9maS1zeW50aGVsYWJvLmNvbTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlNlcXVlbmNlIGlkZW50aWZpY2F0aW9uIGFuZCBjaGFyYWN0ZXJp

emF0aW9uIG9mIGh1bWFuIGNhcm5vc2luYXNlIGFuZCBhIGNsb3NlbHkgcmVsYXRlZCBub24tc3Bl

Y2lmaWMgZGlwZXB0aWRhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBCaW9sIENoZW08L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hlbWlz

dHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9sIENo

ZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3Ry

eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9s

IENoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1p

c3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY1MjEtMzE8L3BhZ2VzPjx2b2x1

bWU+Mjc4PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwMi8xMi8xMTwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5

d29yZD5CYXNlIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluL2Vuenltb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2xvbmluZywgTW9sZWN1bGFyPC9rZXl3b3JkPjxrZXl3b3JkPkRpcGVw

dGlkYXNlcy8gY2hlbWlzdHJ5LyBnZW5ldGljcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkV4cHJlc3NlZCBTZXF1ZW5jZSBUYWdzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgVmVjdG9y

czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vaGlzdG9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TW9s

ZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YWdlbmVzaXMsIFNpdGUt

RGlyZWN0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHNldWRvbW9uYXMvZW56eW1vbG9neTwva2V5d29y

ZD48a2V5d29yZD5SZWNvbWJpbmFudCBQcm90ZWlucy9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdv

cmQ+U2VxdWVuY2UgQWxpZ25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEhvbW9sb2d5

LCBBbWlubyBBY2lkPC9rZXl3b3JkPjxrZXl3b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5

d29yZD48a2V5d29yZD5nYW1tYS1HbHV0YW15bCBIeWRyb2xhc2U8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjEtOTI1OCAoUHJpbnQpJiN4RDswMDIxLTkyNTgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyNDczNjc2PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA3NC9qYmMuTTIwOTc2NDIw

MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [9]. В отличие от CN1, CN2 экспрессируется повсеместно в тканях человека и является цитозольным ферментом. Больше всего этого фермента содержится в почках и печени, в меньшем количестве обнаружен в мозге, селезенке и поджелудочной железе, следовые количества – в легких, семенниках и яичниках, отсутствует в сердце PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzldPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj45OTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGV1ZmVsLCBNLjwvYXV0aG9yPjxhdXRob3I+U2F1

ZGVrLCBWLjwvYXV0aG9yPjxhdXRob3I+TGVkaWcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5CZXJu

aGFyZHQsIEEuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYXJhbmQsIFMuPC9hdXRob3I+PGF1dGhvcj5D

YXJyZWF1LCBBLjwvYXV0aG9yPjxhdXRob3I+Q2Fpcm5zLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

Q2FydGVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Q293bGV5LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+

RHV2ZXJnZXIsIEQuPC9hdXRob3I+PGF1dGhvcj5HYW56aG9ybiwgQS4gSi48L2F1dGhvcj48YXV0

aG9yPkd1ZW5ldCwgQy48L2F1dGhvcj48YXV0aG9yPkhlaW50emVsbWFubiwgQi48L2F1dGhvcj48

YXV0aG9yPkxhdWNoZXIsIFYuPC9hdXRob3I+PGF1dGhvcj5TYXV2YWdlLCBDLjwvYXV0aG9yPjxh

dXRob3I+U21pcm5vdmEsIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFeHBsb3JhdG9yeSBSZXNlYXJjaCwgU2Fub2ZpIFN5bnRo

ZWxhYm8gUmVjaGVyY2hlLCAxNiBSdWUgZCZhcG9zO0Fua2FyYSwgRi02NzA4MCBTdHJhc2JvdXJn

LCBGcmFuY2UuIG1pY2hhZWwudGV1ZmVsQHNhbm9maS1zeW50aGVsYWJvLmNvbTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlNlcXVlbmNlIGlkZW50aWZpY2F0aW9uIGFuZCBjaGFyYWN0ZXJp

emF0aW9uIG9mIGh1bWFuIGNhcm5vc2luYXNlIGFuZCBhIGNsb3NlbHkgcmVsYXRlZCBub24tc3Bl

Y2lmaWMgZGlwZXB0aWRhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBCaW9sIENoZW08L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hlbWlz

dHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9sIENo

ZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3Ry

eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9s

IENoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1p

c3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY1MjEtMzE8L3BhZ2VzPjx2b2x1

bWU+Mjc4PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwMi8xMi8xMTwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5

d29yZD5CYXNlIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluL2Vuenltb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2xvbmluZywgTW9sZWN1bGFyPC9rZXl3b3JkPjxrZXl3b3JkPkRpcGVw

dGlkYXNlcy8gY2hlbWlzdHJ5LyBnZW5ldGljcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkV4cHJlc3NlZCBTZXF1ZW5jZSBUYWdzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgVmVjdG9y

czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vaGlzdG9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TW9s

ZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YWdlbmVzaXMsIFNpdGUt

RGlyZWN0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHNldWRvbW9uYXMvZW56eW1vbG9neTwva2V5d29y

ZD48a2V5d29yZD5SZWNvbWJpbmFudCBQcm90ZWlucy9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdv

cmQ+U2VxdWVuY2UgQWxpZ25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEhvbW9sb2d5

LCBBbWlubyBBY2lkPC9rZXl3b3JkPjxrZXl3b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5

d29yZD48a2V5d29yZD5nYW1tYS1HbHV0YW15bCBIeWRyb2xhc2U8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjEtOTI1OCAoUHJpbnQpJiN4RDswMDIxLTkyNTgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyNDczNjc2PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA3NC9qYmMuTTIwOTc2NDIw

MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzldPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj45OTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGV1ZmVsLCBNLjwvYXV0aG9yPjxhdXRob3I+U2F1

ZGVrLCBWLjwvYXV0aG9yPjxhdXRob3I+TGVkaWcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5CZXJu

aGFyZHQsIEEuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYXJhbmQsIFMuPC9hdXRob3I+PGF1dGhvcj5D

YXJyZWF1LCBBLjwvYXV0aG9yPjxhdXRob3I+Q2Fpcm5zLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

Q2FydGVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Q293bGV5LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+

RHV2ZXJnZXIsIEQuPC9hdXRob3I+PGF1dGhvcj5HYW56aG9ybiwgQS4gSi48L2F1dGhvcj48YXV0

aG9yPkd1ZW5ldCwgQy48L2F1dGhvcj48YXV0aG9yPkhlaW50emVsbWFubiwgQi48L2F1dGhvcj48

YXV0aG9yPkxhdWNoZXIsIFYuPC9hdXRob3I+PGF1dGhvcj5TYXV2YWdlLCBDLjwvYXV0aG9yPjxh

dXRob3I+U21pcm5vdmEsIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFeHBsb3JhdG9yeSBSZXNlYXJjaCwgU2Fub2ZpIFN5bnRo

ZWxhYm8gUmVjaGVyY2hlLCAxNiBSdWUgZCZhcG9zO0Fua2FyYSwgRi02NzA4MCBTdHJhc2JvdXJn

LCBGcmFuY2UuIG1pY2hhZWwudGV1ZmVsQHNhbm9maS1zeW50aGVsYWJvLmNvbTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlNlcXVlbmNlIGlkZW50aWZpY2F0aW9uIGFuZCBjaGFyYWN0ZXJp

emF0aW9uIG9mIGh1bWFuIGNhcm5vc2luYXNlIGFuZCBhIGNsb3NlbHkgcmVsYXRlZCBub24tc3Bl

Y2lmaWMgZGlwZXB0aWRhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBCaW9sIENoZW08L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hlbWlz

dHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9sIENo

ZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3Ry

eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9s

IENoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1p

c3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY1MjEtMzE8L3BhZ2VzPjx2b2x1

bWU+Mjc4PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwMi8xMi8xMTwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5

d29yZD5CYXNlIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluL2Vuenltb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2xvbmluZywgTW9sZWN1bGFyPC9rZXl3b3JkPjxrZXl3b3JkPkRpcGVw

dGlkYXNlcy8gY2hlbWlzdHJ5LyBnZW5ldGljcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkV4cHJlc3NlZCBTZXF1ZW5jZSBUYWdzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgVmVjdG9y

czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vaGlzdG9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TW9s

ZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YWdlbmVzaXMsIFNpdGUt

RGlyZWN0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHNldWRvbW9uYXMvZW56eW1vbG9neTwva2V5d29y

ZD48a2V5d29yZD5SZWNvbWJpbmFudCBQcm90ZWlucy9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdv

cmQ+U2VxdWVuY2UgQWxpZ25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEhvbW9sb2d5

LCBBbWlubyBBY2lkPC9rZXl3b3JkPjxrZXl3b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5

d29yZD48a2V5d29yZD5nYW1tYS1HbHV0YW15bCBIeWRyb2xhc2U8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjEtOTI1OCAoUHJpbnQpJiN4RDswMDIxLTkyNTgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyNDczNjc2PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA3NC9qYmMuTTIwOTc2NDIw

MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [9]. Ферменты характеризуются разными рН-оптимумами работы. CN1 демонстрирует наибольшую активность при рН 7,5 – 8,5, CN2 характеризуется более узким оптимумом работы рН с максимумом около рН 9,5. Таким образом, при физиологических pH карнозин гидролизуется преимущественно с помощью CN1 PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzldPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj45OTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGV1ZmVsLCBNLjwvYXV0aG9yPjxhdXRob3I+U2F1

ZGVrLCBWLjwvYXV0aG9yPjxhdXRob3I+TGVkaWcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5CZXJu

aGFyZHQsIEEuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYXJhbmQsIFMuPC9hdXRob3I+PGF1dGhvcj5D

YXJyZWF1LCBBLjwvYXV0aG9yPjxhdXRob3I+Q2Fpcm5zLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

Q2FydGVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Q293bGV5LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+

RHV2ZXJnZXIsIEQuPC9hdXRob3I+PGF1dGhvcj5HYW56aG9ybiwgQS4gSi48L2F1dGhvcj48YXV0

aG9yPkd1ZW5ldCwgQy48L2F1dGhvcj48YXV0aG9yPkhlaW50emVsbWFubiwgQi48L2F1dGhvcj48

YXV0aG9yPkxhdWNoZXIsIFYuPC9hdXRob3I+PGF1dGhvcj5TYXV2YWdlLCBDLjwvYXV0aG9yPjxh

dXRob3I+U21pcm5vdmEsIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFeHBsb3JhdG9yeSBSZXNlYXJjaCwgU2Fub2ZpIFN5bnRo

ZWxhYm8gUmVjaGVyY2hlLCAxNiBSdWUgZCZhcG9zO0Fua2FyYSwgRi02NzA4MCBTdHJhc2JvdXJn

LCBGcmFuY2UuIG1pY2hhZWwudGV1ZmVsQHNhbm9maS1zeW50aGVsYWJvLmNvbTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlNlcXVlbmNlIGlkZW50aWZpY2F0aW9uIGFuZCBjaGFyYWN0ZXJp

emF0aW9uIG9mIGh1bWFuIGNhcm5vc2luYXNlIGFuZCBhIGNsb3NlbHkgcmVsYXRlZCBub24tc3Bl

Y2lmaWMgZGlwZXB0aWRhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBCaW9sIENoZW08L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hlbWlz

dHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9sIENo

ZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3Ry

eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9s

IENoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1p

c3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY1MjEtMzE8L3BhZ2VzPjx2b2x1

bWU+Mjc4PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwMi8xMi8xMTwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5

d29yZD5CYXNlIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluL2Vuenltb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2xvbmluZywgTW9sZWN1bGFyPC9rZXl3b3JkPjxrZXl3b3JkPkRpcGVw

dGlkYXNlcy8gY2hlbWlzdHJ5LyBnZW5ldGljcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkV4cHJlc3NlZCBTZXF1ZW5jZSBUYWdzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgVmVjdG9y

czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vaGlzdG9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TW9s

ZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YWdlbmVzaXMsIFNpdGUt

RGlyZWN0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHNldWRvbW9uYXMvZW56eW1vbG9neTwva2V5d29y

ZD48a2V5d29yZD5SZWNvbWJpbmFudCBQcm90ZWlucy9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdv

cmQ+U2VxdWVuY2UgQWxpZ25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEhvbW9sb2d5

LCBBbWlubyBBY2lkPC9rZXl3b3JkPjxrZXl3b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5

d29yZD48a2V5d29yZD5nYW1tYS1HbHV0YW15bCBIeWRyb2xhc2U8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjEtOTI1OCAoUHJpbnQpJiN4RDswMDIxLTkyNTgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyNDczNjc2PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA3NC9qYmMuTTIwOTc2NDIw

MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzldPC9EaXNwbGF5VGV4dD48cmVjb3JkPjxy

ZWMtbnVtYmVyPjk5PC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1p

ZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj45OTwva2V5PjwvZm9yZWln

bi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48Y29u

dHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+VGV1ZmVsLCBNLjwvYXV0aG9yPjxhdXRob3I+U2F1

ZGVrLCBWLjwvYXV0aG9yPjxhdXRob3I+TGVkaWcsIEouIFAuPC9hdXRob3I+PGF1dGhvcj5CZXJu

aGFyZHQsIEEuPC9hdXRob3I+PGF1dGhvcj5Cb3VsYXJhbmQsIFMuPC9hdXRob3I+PGF1dGhvcj5D

YXJyZWF1LCBBLjwvYXV0aG9yPjxhdXRob3I+Q2Fpcm5zLCBOLiBKLjwvYXV0aG9yPjxhdXRob3I+

Q2FydGVyLCBDLjwvYXV0aG9yPjxhdXRob3I+Q293bGV5LCBELiBKLjwvYXV0aG9yPjxhdXRob3I+

RHV2ZXJnZXIsIEQuPC9hdXRob3I+PGF1dGhvcj5HYW56aG9ybiwgQS4gSi48L2F1dGhvcj48YXV0

aG9yPkd1ZW5ldCwgQy48L2F1dGhvcj48YXV0aG9yPkhlaW50emVsbWFubiwgQi48L2F1dGhvcj48

YXV0aG9yPkxhdWNoZXIsIFYuPC9hdXRob3I+PGF1dGhvcj5TYXV2YWdlLCBDLjwvYXV0aG9yPjxh

dXRob3I+U21pcm5vdmEsIFQuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRo

LWFkZHJlc3M+RGVwYXJ0bWVudCBvZiBFeHBsb3JhdG9yeSBSZXNlYXJjaCwgU2Fub2ZpIFN5bnRo

ZWxhYm8gUmVjaGVyY2hlLCAxNiBSdWUgZCZhcG9zO0Fua2FyYSwgRi02NzA4MCBTdHJhc2JvdXJn

LCBGcmFuY2UuIG1pY2hhZWwudGV1ZmVsQHNhbm9maS1zeW50aGVsYWJvLmNvbTwvYXV0aC1hZGRy

ZXNzPjx0aXRsZXM+PHRpdGxlPlNlcXVlbmNlIGlkZW50aWZpY2F0aW9uIGFuZCBjaGFyYWN0ZXJp

emF0aW9uIG9mIGh1bWFuIGNhcm5vc2luYXNlIGFuZCBhIGNsb3NlbHkgcmVsYXRlZCBub24tc3Bl

Y2lmaWMgZGlwZXB0aWRhc2U8L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBCaW9sIENoZW08L3Nl

Y29uZGFyeS10aXRsZT48YWx0LXRpdGxlPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hlbWlz

dHJ5PC9hbHQtdGl0bGU+PC90aXRsZXM+PHBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9sIENo

ZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3Ry

eTwvYWJici0xPjwvcGVyaW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+SiBCaW9s

IENoZW08L2Z1bGwtdGl0bGU+PGFiYnItMT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1p

c3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjY1MjEtMzE8L3BhZ2VzPjx2b2x1

bWU+Mjc4PC92b2x1bWU+PG51bWJlcj44PC9udW1iZXI+PGVkaXRpb24+MjAwMi8xMi8xMTwvZWRp

dGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5

d29yZD5CYXNlIFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkJyYWluL2Vuenltb2xvZ3k8L2tl

eXdvcmQ+PGtleXdvcmQ+Q2xvbmluZywgTW9sZWN1bGFyPC9rZXl3b3JkPjxrZXl3b3JkPkRpcGVw

dGlkYXNlcy8gY2hlbWlzdHJ5LyBnZW5ldGljcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkV4cHJlc3NlZCBTZXF1ZW5jZSBUYWdzPC9rZXl3b3JkPjxrZXl3b3JkPkdlbmV0aWMgVmVjdG9y

czwva2V5d29yZD48a2V5d29yZD5IdW1hbnM8L2tleXdvcmQ+PGtleXdvcmQ+SW1tdW5vaGlzdG9j

aGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdvcmQ+TW9s

ZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+TXV0YWdlbmVzaXMsIFNpdGUt

RGlyZWN0ZWQ8L2tleXdvcmQ+PGtleXdvcmQ+UHNldWRvbW9uYXMvZW56eW1vbG9neTwva2V5d29y

ZD48a2V5d29yZD5SZWNvbWJpbmFudCBQcm90ZWlucy9jaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdv

cmQ+U2VxdWVuY2UgQWxpZ25tZW50PC9rZXl3b3JkPjxrZXl3b3JkPlNlcXVlbmNlIEhvbW9sb2d5

LCBBbWlubyBBY2lkPC9rZXl3b3JkPjxrZXl3b3JkPlN1YnN0cmF0ZSBTcGVjaWZpY2l0eTwva2V5

d29yZD48a2V5d29yZD5nYW1tYS1HbHV0YW15bCBIeWRyb2xhc2U8L2tleXdvcmQ+PC9rZXl3b3Jk

cz48ZGF0ZXM+PHllYXI+MjAwMzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAyMTwvZGF0ZT48

L3B1Yi1kYXRlcz48L2RhdGVzPjxpc2JuPjAwMjEtOTI1OCAoUHJpbnQpJiN4RDswMDIxLTkyNTgg

KExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjEyNDczNjc2PC9hY2Nlc3Npb24tbnVtPjx1

cmxzPjwvdXJscz48ZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+MTAuMTA3NC9qYmMuTTIwOTc2NDIw

MDwvZWxlY3Ryb25pYy1yZXNvdXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08

L3JlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29y

ZD48L0NpdGU+PC9FbmROb3RlPgB=

ADDIN EN.CITE.DATA [9]. Интересно отметить, что экспрессия CN1 отсутствует в пренатальном периоде и у новорожденных, что указывает на усиление экспрессии CN1 с возрастом PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzksIDE5Nl08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+OTk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjk5PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5UZXVmZWwsIE0uPC9hdXRob3I+PGF1dGhv

cj5TYXVkZWssIFYuPC9hdXRob3I+PGF1dGhvcj5MZWRpZywgSi4gUC48L2F1dGhvcj48YXV0aG9y

PkJlcm5oYXJkdCwgQS48L2F1dGhvcj48YXV0aG9yPkJvdWxhcmFuZCwgUy48L2F1dGhvcj48YXV0

aG9yPkNhcnJlYXUsIEEuPC9hdXRob3I+PGF1dGhvcj5DYWlybnMsIE4uIEouPC9hdXRob3I+PGF1

dGhvcj5DYXJ0ZXIsIEMuPC9hdXRob3I+PGF1dGhvcj5Db3dsZXksIEQuIEouPC9hdXRob3I+PGF1

dGhvcj5EdXZlcmdlciwgRC48L2F1dGhvcj48YXV0aG9yPkdhbnpob3JuLCBBLiBKLjwvYXV0aG9y

PjxhdXRob3I+R3VlbmV0LCBDLjwvYXV0aG9yPjxhdXRob3I+SGVpbnR6ZWxtYW5uLCBCLjwvYXV0

aG9yPjxhdXRob3I+TGF1Y2hlciwgVi48L2F1dGhvcj48YXV0aG9yPlNhdXZhZ2UsIEMuPC9hdXRo

b3I+PGF1dGhvcj5TbWlybm92YSwgVC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEV4cGxvcmF0b3J5IFJlc2VhcmNoLCBTYW5vZmkg

U3ludGhlbGFibyBSZWNoZXJjaGUsIDE2IFJ1ZSBkJmFwb3M7QW5rYXJhLCBGLTY3MDgwIFN0cmFz

Ym91cmcsIEZyYW5jZS4gbWljaGFlbC50ZXVmZWxAc2Fub2ZpLXN5bnRoZWxhYm8uY29tPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U2VxdWVuY2UgaWRlbnRpZmljYXRpb24gYW5kIGNoYXJh

Y3Rlcml6YXRpb24gb2YgaHVtYW4gY2Fybm9zaW5hc2UgYW5kIGEgY2xvc2VseSByZWxhdGVkIG5v

bi1zcGVjaWZpYyBkaXBlcHRpZGFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEJpb2wgQ2hl

bTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBj

aGVtaXN0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEJp

b2wgQ2hlbTwvZnVsbC10aXRsZT48YWJici0xPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hl

bWlzdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

IEJpb2wgQ2hlbTwvZnVsbC10aXRsZT48YWJici0xPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwg

Y2hlbWlzdHJ5PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjUyMS0zMTwvcGFnZXM+

PHZvbHVtZT4yNzg8L3ZvbHVtZT48bnVtYmVyPjg8L251bWJlcj48ZWRpdGlvbj4yMDAyLzEyLzEx

PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BbWlubyBBY2lkIFNlcXVlbmNlPC9rZXl3b3Jk

PjxrZXl3b3JkPkJhc2UgU2VxdWVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+QnJhaW4vZW56eW1vbG9n

eTwva2V5d29yZD48a2V5d29yZD5DbG9uaW5nLCBNb2xlY3VsYXI8L2tleXdvcmQ+PGtleXdvcmQ+

RGlwZXB0aWRhc2VzLyBjaGVtaXN0cnkvIGdlbmV0aWNzL21ldGFib2xpc208L2tleXdvcmQ+PGtl

eXdvcmQ+RXhwcmVzc2VkIFNlcXVlbmNlIFRhZ3M8L2tleXdvcmQ+PGtleXdvcmQ+R2VuZXRpYyBW

ZWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9o

aXN0b2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5LaW5ldGljczwva2V5d29yZD48a2V5d29y

ZD5Nb2xlY3VsYXIgU2VxdWVuY2UgRGF0YTwva2V5d29yZD48a2V5d29yZD5NdXRhZ2VuZXNpcywg

U2l0ZS1EaXJlY3RlZDwva2V5d29yZD48a2V5d29yZD5Qc2V1ZG9tb25hcy9lbnp5bW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPlJlY29tYmluYW50IFByb3RlaW5zL2NoZW1pc3RyeTwva2V5d29yZD48

a2V5d29yZD5TZXF1ZW5jZSBBbGlnbm1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+U2VxdWVuY2UgSG9t

b2xvZ3ksIEFtaW5vIEFjaWQ8L2tleXdvcmQ+PGtleXdvcmQ+U3Vic3RyYXRlIFNwZWNpZmljaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPmdhbW1hLUdsdXRhbXlsIEh5ZHJvbGFzZTwva2V5d29yZD48L2tl

eXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViIDIxPC9k

YXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAyMS05MjU4IChQcmludCkmI3hEOzAwMjEt

OTI1OCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTI0NzM2NzY8L2FjY2Vzc2lvbi1u

dW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMjA5

NzY0MjAwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

Pk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkJhbmRvPC9BdXRob3I+PFllYXI+MTk4NDwvWWVh

cj48UmVjTnVtPjMyOTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MzI5PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1

YWE4c3hzYTU5OWVldjJzIj4zMjk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkJhbmRvLCBLLjwvYXV0aG9yPjxhdXRob3I+U2hpbW90c3VqaSwgVC48L2F1dGhvcj48YXV0

aG9yPlRveW9zaGltYSwgSC48L2F1dGhvcj48YXV0aG9yPkhheWFzaGksIEMuPC9hdXRob3I+PGF1

dGhvcj5NaXlhaSwgSy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48

dGl0bGU+Rmx1b3JvbWV0cmljIGFzc2F5IG9mIGh1bWFuIHNlcnVtIGNhcm5vc2luYXNlIGFjdGl2

aXR5IGluIG5vcm1hbCBjaGlsZHJlbiwgYWR1bHRzIGFuZCBwYXRpZW50cyB3aXRoIG15b3BhdGh5

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFubiBDbGluIEJpb2NoZW08L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFubmFscyBvZiBjbGluaWNhbCBiaW9jaGVtaXN0cnk8L2FsdC10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Bbm4gQ2xpbiBCaW9jaGVtPC9mdWxsLXRp

dGxlPjxhYmJyLTE+QW5uYWxzIG9mIGNsaW5pY2FsIGJpb2NoZW1pc3RyeTwvYWJici0xPjwvcGVy

aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW5uIENsaW4gQmlvY2hlbTwvZnVs

bC10aXRsZT48YWJici0xPkFubmFscyBvZiBjbGluaWNhbCBiaW9jaGVtaXN0cnk8L2FiYnItMT48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MTAtNDwvcGFnZXM+PHZvbHVtZT4yMSAoIFB0IDYpPC92

b2x1bWU+PGVkaXRpb24+MTk4NC8xMS8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1

bHQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNj

aG9vbDwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGFzZXMvIGJsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IaXN0aWRpbmUvYmxvb2Q8L2tleXdvcmQ+PGtl

eXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD5J

bmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdv

cmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NdXNjdWxhciBEaXNlYXNlcy8gZW56eW1vbG9neTwv

a2V5d29yZD48a2V5d29yZD5TcGVjdHJvbWV0cnksIEZsdW9yZXNjZW5jZS9tZXRob2RzPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5ODQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5O

b3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA0LTU2MzIgKFByaW50KSYjeEQ7

MDAwNC01NjMyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT42NTE3NDkyPC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48L0VuZE5vdGU+

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5UZXVmZWw8L0F1dGhvcj48WWVhcj4yMDAzPC9ZZWFyPjxS

ZWNOdW0+OTk8L1JlY051bT48RGlzcGxheVRleHQ+WzksIDE5Nl08L0Rpc3BsYXlUZXh0PjxyZWNv

cmQ+PHJlYy1udW1iZXI+OTk8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjk5PC9rZXk+PC9m

b3JlaWduLWtleXM+PHJlZi10eXBlIG5hbWU9IkpvdXJuYWwgQXJ0aWNsZSI+MTc8L3JlZi10eXBl

Pjxjb250cmlidXRvcnM+PGF1dGhvcnM+PGF1dGhvcj5UZXVmZWwsIE0uPC9hdXRob3I+PGF1dGhv

cj5TYXVkZWssIFYuPC9hdXRob3I+PGF1dGhvcj5MZWRpZywgSi4gUC48L2F1dGhvcj48YXV0aG9y

PkJlcm5oYXJkdCwgQS48L2F1dGhvcj48YXV0aG9yPkJvdWxhcmFuZCwgUy48L2F1dGhvcj48YXV0

aG9yPkNhcnJlYXUsIEEuPC9hdXRob3I+PGF1dGhvcj5DYWlybnMsIE4uIEouPC9hdXRob3I+PGF1

dGhvcj5DYXJ0ZXIsIEMuPC9hdXRob3I+PGF1dGhvcj5Db3dsZXksIEQuIEouPC9hdXRob3I+PGF1

dGhvcj5EdXZlcmdlciwgRC48L2F1dGhvcj48YXV0aG9yPkdhbnpob3JuLCBBLiBKLjwvYXV0aG9y

PjxhdXRob3I+R3VlbmV0LCBDLjwvYXV0aG9yPjxhdXRob3I+SGVpbnR6ZWxtYW5uLCBCLjwvYXV0

aG9yPjxhdXRob3I+TGF1Y2hlciwgVi48L2F1dGhvcj48YXV0aG9yPlNhdXZhZ2UsIEMuPC9hdXRo

b3I+PGF1dGhvcj5TbWlybm92YSwgVC48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+

PGF1dGgtYWRkcmVzcz5EZXBhcnRtZW50IG9mIEV4cGxvcmF0b3J5IFJlc2VhcmNoLCBTYW5vZmkg

U3ludGhlbGFibyBSZWNoZXJjaGUsIDE2IFJ1ZSBkJmFwb3M7QW5rYXJhLCBGLTY3MDgwIFN0cmFz

Ym91cmcsIEZyYW5jZS4gbWljaGFlbC50ZXVmZWxAc2Fub2ZpLXN5bnRoZWxhYm8uY29tPC9hdXRo

LWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+U2VxdWVuY2UgaWRlbnRpZmljYXRpb24gYW5kIGNoYXJh

Y3Rlcml6YXRpb24gb2YgaHVtYW4gY2Fybm9zaW5hc2UgYW5kIGEgY2xvc2VseSByZWxhdGVkIG5v

bi1zcGVjaWZpYyBkaXBlcHRpZGFzZTwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5KIEJpb2wgQ2hl

bTwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBj

aGVtaXN0cnk8L2FsdC10aXRsZT48L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIEJp

b2wgQ2hlbTwvZnVsbC10aXRsZT48YWJici0xPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwgY2hl

bWlzdHJ5PC9hYmJyLTE+PC9wZXJpb2RpY2FsPjxhbHQtcGVyaW9kaWNhbD48ZnVsbC10aXRsZT5K

IEJpb2wgQ2hlbTwvZnVsbC10aXRsZT48YWJici0xPlRoZSBKb3VybmFsIG9mIGJpb2xvZ2ljYWwg

Y2hlbWlzdHJ5PC9hYmJyLTE+PC9hbHQtcGVyaW9kaWNhbD48cGFnZXM+NjUyMS0zMTwvcGFnZXM+

PHZvbHVtZT4yNzg8L3ZvbHVtZT48bnVtYmVyPjg8L251bWJlcj48ZWRpdGlvbj4yMDAyLzEyLzEx

PC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BbWlubyBBY2lkIFNlcXVlbmNlPC9rZXl3b3Jk

PjxrZXl3b3JkPkJhc2UgU2VxdWVuY2U8L2tleXdvcmQ+PGtleXdvcmQ+QnJhaW4vZW56eW1vbG9n

eTwva2V5d29yZD48a2V5d29yZD5DbG9uaW5nLCBNb2xlY3VsYXI8L2tleXdvcmQ+PGtleXdvcmQ+

RGlwZXB0aWRhc2VzLyBjaGVtaXN0cnkvIGdlbmV0aWNzL21ldGFib2xpc208L2tleXdvcmQ+PGtl

eXdvcmQ+RXhwcmVzc2VkIFNlcXVlbmNlIFRhZ3M8L2tleXdvcmQ+PGtleXdvcmQ+R2VuZXRpYyBW

ZWN0b3JzPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5JbW11bm9o

aXN0b2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5LaW5ldGljczwva2V5d29yZD48a2V5d29y

ZD5Nb2xlY3VsYXIgU2VxdWVuY2UgRGF0YTwva2V5d29yZD48a2V5d29yZD5NdXRhZ2VuZXNpcywg

U2l0ZS1EaXJlY3RlZDwva2V5d29yZD48a2V5d29yZD5Qc2V1ZG9tb25hcy9lbnp5bW9sb2d5PC9r

ZXl3b3JkPjxrZXl3b3JkPlJlY29tYmluYW50IFByb3RlaW5zL2NoZW1pc3RyeTwva2V5d29yZD48

a2V5d29yZD5TZXF1ZW5jZSBBbGlnbm1lbnQ8L2tleXdvcmQ+PGtleXdvcmQ+U2VxdWVuY2UgSG9t

b2xvZ3ksIEFtaW5vIEFjaWQ8L2tleXdvcmQ+PGtleXdvcmQ+U3Vic3RyYXRlIFNwZWNpZmljaXR5

PC9rZXl3b3JkPjxrZXl3b3JkPmdhbW1hLUdsdXRhbXlsIEh5ZHJvbGFzZTwva2V5d29yZD48L2tl

eXdvcmRzPjxkYXRlcz48eWVhcj4yMDAzPC95ZWFyPjxwdWItZGF0ZXM+PGRhdGU+RmViIDIxPC9k

YXRlPjwvcHViLWRhdGVzPjwvZGF0ZXM+PGlzYm4+MDAyMS05MjU4IChQcmludCkmI3hEOzAwMjEt

OTI1OCAoTGlua2luZyk8L2lzYm4+PGFjY2Vzc2lvbi1udW0+MTI0NzM2NzY8L2FjY2Vzc2lvbi1u

dW0+PHVybHM+PC91cmxzPjxlbGVjdHJvbmljLXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMjA5

NzY0MjAwPC9lbGVjdHJvbmljLXJlc291cmNlLW51bT48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVy

Pk5MTTwvcmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwv

cmVjb3JkPjwvQ2l0ZT48Q2l0ZT48QXV0aG9yPkJhbmRvPC9BdXRob3I+PFllYXI+MTk4NDwvWWVh

cj48UmVjTnVtPjMyOTwvUmVjTnVtPjxyZWNvcmQ+PHJlYy1udW1iZXI+MzI5PC9yZWMtbnVtYmVy

Pjxmb3JlaWduLWtleXM+PGtleSBhcHA9IkVOIiBkYi1pZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1

YWE4c3hzYTU5OWVldjJzIj4zMjk8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0i

Sm91cm5hbCBBcnRpY2xlIj4xNzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0

aG9yPkJhbmRvLCBLLjwvYXV0aG9yPjxhdXRob3I+U2hpbW90c3VqaSwgVC48L2F1dGhvcj48YXV0

aG9yPlRveW9zaGltYSwgSC48L2F1dGhvcj48YXV0aG9yPkhheWFzaGksIEMuPC9hdXRob3I+PGF1

dGhvcj5NaXlhaSwgSy48L2F1dGhvcj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PHRpdGxlcz48

dGl0bGU+Rmx1b3JvbWV0cmljIGFzc2F5IG9mIGh1bWFuIHNlcnVtIGNhcm5vc2luYXNlIGFjdGl2

aXR5IGluIG5vcm1hbCBjaGlsZHJlbiwgYWR1bHRzIGFuZCBwYXRpZW50cyB3aXRoIG15b3BhdGh5

PC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkFubiBDbGluIEJpb2NoZW08L3NlY29uZGFyeS10aXRs

ZT48YWx0LXRpdGxlPkFubmFscyBvZiBjbGluaWNhbCBiaW9jaGVtaXN0cnk8L2FsdC10aXRsZT48

L3RpdGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5Bbm4gQ2xpbiBCaW9jaGVtPC9mdWxsLXRp

dGxlPjxhYmJyLTE+QW5uYWxzIG9mIGNsaW5pY2FsIGJpb2NoZW1pc3RyeTwvYWJici0xPjwvcGVy

aW9kaWNhbD48YWx0LXBlcmlvZGljYWw+PGZ1bGwtdGl0bGU+QW5uIENsaW4gQmlvY2hlbTwvZnVs

bC10aXRsZT48YWJici0xPkFubmFscyBvZiBjbGluaWNhbCBiaW9jaGVtaXN0cnk8L2FiYnItMT48

L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz41MTAtNDwvcGFnZXM+PHZvbHVtZT4yMSAoIFB0IDYpPC92

b2x1bWU+PGVkaXRpb24+MTk4NC8xMS8wMTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWR1

bHQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQ8L2tleXdvcmQ+PGtleXdvcmQ+Q2hpbGQsIFByZXNj

aG9vbDwva2V5d29yZD48a2V5d29yZD5EaXBlcHRpZGFzZXMvIGJsb29kPC9rZXl3b3JkPjxrZXl3

b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IaXN0aWRpbmUvYmxvb2Q8L2tleXdvcmQ+PGtl

eXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPkluZmFudDwva2V5d29yZD48a2V5d29yZD5J

bmZhbnQsIE5ld2Jvcm48L2tleXdvcmQ+PGtleXdvcmQ+S2luZXRpY3M8L2tleXdvcmQ+PGtleXdv

cmQ+TWFsZTwva2V5d29yZD48a2V5d29yZD5NdXNjdWxhciBEaXNlYXNlcy8gZW56eW1vbG9neTwv

a2V5d29yZD48a2V5d29yZD5TcGVjdHJvbWV0cnksIEZsdW9yZXNjZW5jZS9tZXRob2RzPC9rZXl3

b3JkPjwva2V5d29yZHM+PGRhdGVzPjx5ZWFyPjE5ODQ8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5O

b3Y8L2RhdGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4wMDA0LTU2MzIgKFByaW50KSYjeEQ7

MDAwNC01NjMyIChMaW5raW5nKTwvaXNibj48YWNjZXNzaW9uLW51bT42NTE3NDkyPC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48cmVtb3RlLWRhdGFiYXNlLXByb3ZpZGVyPk5MTTwvcmVtb3Rl

LWRhdGFiYXNlLXByb3ZpZGVyPjxsYW5ndWFnZT5lbmc8L2xhbmd1YWdlPjwvcmVjb3JkPjwvQ2l0

ZT48L0VuZE5vdGU+

ADDIN EN.CITE.DATA [9, 196]. Кроме того, у пожилых людей обнаружен более низкий уровень гомокарнозина в сыворотке крови по сравнению с молодым поколением ADDIN EN.CITE <EndNote><Cite><Author>Perry</Author><Year>1968</Year><RecNum>331</RecNum><DisplayText>[197]</DisplayText><record><rec-number>331</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">331</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Perry, T. L.</author><author>Hansen, S.</author><author>Stedman, D.</author><author>Love, D.</author></authors></contributors><titles><title>Homocarnosine in human cerebrospinal fluid: an age-dependent phenomenon</title><secondary-title>J Neurochem</secondary-title><alt-title>Journal of neurochemistry</alt-title></titles><periodical><full-title>J Neurochem</full-title><abbr-1>Journal of neurochemistry</abbr-1></periodical><alt-periodical><full-title>J Neurochem</full-title><abbr-1>Journal of neurochemistry</abbr-1></alt-periodical><pages>1203-6</pages><volume>15</volume><number>10</number><edition>1968/10/01</edition><keywords><keyword>Adolescent</keyword><keyword>Adult</keyword><keyword>Age Factors</keyword><keyword>Aged</keyword><keyword>Amides/ cerebrospinal fluid</keyword><keyword>Amino Acids/cerebrospinal fluid</keyword><keyword>Aminobutyrates/ cerebrospinal fluid</keyword><keyword>Centrifugation</keyword><keyword>Child</keyword><keyword>Child, Preschool</keyword><keyword>Chromatography, Ion Exchange</keyword><keyword>Electrophoresis</keyword><keyword>Humans</keyword><keyword>Imidazoles/ cerebrospinal fluid</keyword><keyword>Infant</keyword><keyword>Intellectual Disability/cerebrospinal fluid</keyword><keyword>Male</keyword><keyword>Middle Aged</keyword><keyword>Nervous System Diseases/cerebrospinal fluid</keyword><keyword>Propionates/ cerebrospinal fluid</keyword></keywords><dates><year>1968</year><pub-dates><date>Oct</date></pub-dates></dates><isbn>0022-3042 (Print)&#xD;0022-3042 (Linking)</isbn><accession-num>5711132</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[197].У карнозина существует несколько природных производных, в том числе: N-ацетил-карнозин (N-ацетил--аланил-L-гистидин), анзерин (-аланил-1-метил-L-гистидин) и гомокарнозин (у-амино-бутирил-L-гистидин) (см. Рис. 1.5). Считается, что -аланил-содержащие дипептиды преимущественно располагаются в скелетных мышцах, в то время как дипептиды содержащие -амино-масленную кислоту (ГАМК) типичны для центральной нервной системы PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ecm96YWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+MTU1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3XTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4xNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE1NTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RHJvemFrLCBKLjwvYXV0aG9yPjxhdXRob3I+

VmVpZ2EtZGEtQ3VuaGEsIE0uPC9hdXRob3I+PGF1dGhvcj5WZXJ0b21tZW4sIEQuPC9hdXRob3I+





PGF1dGhvcj5TdHJvb2JhbnQsIFYuPC9hdXRob3I+PGF1dGhvcj5WYW4gU2NoYWZ0aW5nZW4sIEUu

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TGFib3JhdG9y

eSBvZiBQaHlzaW9sb2dpY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0ZSBDYXRob2xpcXVlIGRlIExv

dXZhaW4sIEF2ZW51ZSBIaXBwb2NyYXRlIDc1LCBCLTEyMDAgQnJ1c3NlbHMsIEJlbGdpdW0uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TW9sZWN1bGFyIGlkZW50aWZpY2F0aW9uIG9mIGNh

cm5vc2luZSBzeW50aGFzZSBhcyBBVFAtZ3Jhc3AgZG9tYWluLWNvbnRhaW5pbmcgcHJvdGVpbiAx

IChBVFBHRDEpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9mdWxs

LXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2FiYnIt

MT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45MzQ2LTU2PC9wYWdlcz48dm9sdW1lPjI4NTwv

dm9sdW1lPjxudW1iZXI+MTM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzAxLzI2PC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgTW9ub3Bob3NwaGF0ZS9tZXRhYm9saXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvIGNoZW1pc3RyeTwva2V5d29yZD48

a2V5d29yZD5BbGFuaW5lL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5BbWlubyBBY2lkIFNl

cXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9z

aW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBMaW5lPC9rZXl3b3JkPjxrZXl3

b3JkPkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5N

YXNzIFNwZWN0cm9tZXRyeS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdvcmQ+

PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+UGVwdGlk

ZSBTeW50aGFzZXMvIGdlbmV0aWNzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRp

ZGVzL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBIb21vbG9neSwgQW1pbm8g

QWNpZDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtl

eXdvcmQ+Z2FtbWEtQW1pbm9idXR5cmljIEFjaWQvY2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXIgMjY8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDgzLTM1MVggKEVsZWN0cm9uaWMpJiN4RDswMDIx

LTkyNTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMDk3NzUyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMyODQzMTgzPC9jdXN0b20yPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMTA5LjA5NTUwNTwvZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ecm96YWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+MTU1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls3XTwvRGlzcGxheVRleHQ+PHJlY29yZD48

cmVjLW51bWJlcj4xNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4iIGRi

LWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE1NTwva2V5PjwvZm9y

ZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlwZT48

Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RHJvemFrLCBKLjwvYXV0aG9yPjxhdXRob3I+

VmVpZ2EtZGEtQ3VuaGEsIE0uPC9hdXRob3I+PGF1dGhvcj5WZXJ0b21tZW4sIEQuPC9hdXRob3I+





PGF1dGhvcj5TdHJvb2JhbnQsIFYuPC9hdXRob3I+PGF1dGhvcj5WYW4gU2NoYWZ0aW5nZW4sIEUu

PC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TGFib3JhdG9y

eSBvZiBQaHlzaW9sb2dpY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0ZSBDYXRob2xpcXVlIGRlIExv

dXZhaW4sIEF2ZW51ZSBIaXBwb2NyYXRlIDc1LCBCLTEyMDAgQnJ1c3NlbHMsIEJlbGdpdW0uPC9h

dXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TW9sZWN1bGFyIGlkZW50aWZpY2F0aW9uIG9mIGNh

cm5vc2luZSBzeW50aGFzZSBhcyBBVFAtZ3Jhc3AgZG9tYWluLWNvbnRhaW5pbmcgcHJvdGVpbiAx

IChBVFBHRDEpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRhcnkt

dGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwvYWx0

LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9mdWxs

LXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2FiYnIt

MT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45MzQ2LTU2PC9wYWdlcz48dm9sdW1lPjI4NTwv

dm9sdW1lPjxudW1iZXI+MTM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzAxLzI2PC9lZGl0aW9uPjxr

ZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgTW9ub3Bob3NwaGF0ZS9tZXRhYm9saXNtPC9rZXl3

b3JkPjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvIGNoZW1pc3RyeTwva2V5d29yZD48

a2V5d29yZD5BbGFuaW5lL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5BbWlubyBBY2lkIFNl

cXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9z

aW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBMaW5lPC9rZXl3b3JkPjxrZXl3

b3JkPkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29yZD5N

YXNzIFNwZWN0cm9tZXRyeS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdvcmQ+

PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+UGVwdGlk

ZSBTeW50aGFzZXMvIGdlbmV0aWNzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRp

ZGVzL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBIb21vbG9neSwgQW1pbm8g

QWNpZDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PGtl

eXdvcmQ+Z2FtbWEtQW1pbm9idXR5cmljIEFjaWQvY2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5d29y

ZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXIgMjY8L2RhdGU+

PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDgzLTM1MVggKEVsZWN0cm9uaWMpJiN4RDswMDIx

LTkyNTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMDk3NzUyPC9hY2Nlc3Npb24t

bnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMyODQzMTgzPC9jdXN0b20yPjxlbGVjdHJvbmlj

LXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMTA5LjA5NTUwNTwvZWxlY3Ryb25pYy1yZXNvdXJj

ZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1wcm92

aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PC9FbmROb3RlPn==

ADDIN EN.CITE.DATA [7]. Ацетилированная форма карнозина присутствует в сердечной мышце и в мозге ADDIN EN.CITE <EndNote><Cite><Author>Sobue</Author><Year>1975</Year><RecNum>158</RecNum><DisplayText>[198]</DisplayText><record><rec-number>158</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">158</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Sobue, K.</author><author>Konishi, H.</author><author>Nakajima, T.</author></authors></contributors><titles><title>Isolation and identification of N-acetylhomocarnosine and N-acetylcarnosine from brain and muscle</title><secondary-title>J Neurochem</secondary-title><alt-title>Journal of neurochemistry</alt-title></titles><periodical><full-title>J Neurochem</full-title><abbr-1>Journal of neurochemistry</abbr-1></periodical><alt-periodical><full-title>J Neurochem</full-title><abbr-1>Journal of neurochemistry</abbr-1></alt-periodical><pages>1261-2</pages><volume>24</volume><number>6</number><edition>1975/06/01</edition><keywords><keyword>Acetamides/isolation &amp; purification</keyword><keyword>Animals</keyword><keyword>Brain Chemistry</keyword><keyword>Carnosine/ analogs &amp; derivatives</keyword><keyword>Cattle</keyword><keyword>Chromatography, Ion Exchange</keyword><keyword>Chromatography, Paper</keyword><keyword>Dipeptides/ analogs &amp; derivatives</keyword><keyword>Kidney/analysis</keyword><keyword>Liver/analysis</keyword><keyword>Muscles/ analysis</keyword><keyword>Myocardium/analysis</keyword><keyword>Organ Specificity</keyword><keyword>Rabbits</keyword></keywords><dates><year>1975</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0022-3042 (Print)&#xD;0022-3042 (Linking)</isbn><accession-num>1127438</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[198]. Предполагается, что образование ацетилкарнозина происходит за счет ацетилирования карнозина, однако информация о ферментах, катализирующих данную реакцию пока отсутствует. Гомокарнозин (0,3-1,5 мМ ADDIN EN.CITE <EndNote><Cite><Author>Kish</Author><Year>1979</Year><RecNum>156</RecNum><DisplayText>[199]</DisplayText><record><rec-number>156</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">156</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Kish, S. J.</author><author>Perry, T. L.</author><author>Hansen, S.</author></authors></contributors><titles><title>Regional distribution of homocarnosine, homocarnosine-carnosine synthetase and homocarnosinase in human brain</title><secondary-title>J Neurochem</secondary-title><alt-title>Journal of neurochemistry</alt-title></titles><periodical><full-title>J Neurochem</full-title><abbr-1>Journal of neurochemistry</abbr-1></periodical><alt-periodical><full-title>J Neurochem</full-title><abbr-1>Journal of neurochemistry</abbr-1></alt-periodical><pages>1629-36</pages><volume>32</volume><number>6</number><edition>1979/06/01</edition><keywords><keyword>Adult</keyword><keyword>Alanine</keyword><keyword>Brain/ enzymology</keyword><keyword>Brain Chemistry</keyword><keyword>Carnosine/analogs &amp; derivatives/ analysis/biosynthesis</keyword><keyword>Dipeptidases/ analysis</keyword><keyword>Dipeptides/ analysis</keyword><keyword>Humans</keyword><keyword>Kinetics</keyword><keyword>Peptide Synthases/ analysis</keyword><keyword>Substrate Specificity</keyword><keyword>Tissue Distribution</keyword><keyword>gamma-Aminobutyric Acid</keyword></keywords><dates><year>1979</year><pub-dates><date>Jun</date></pub-dates></dates><isbn>0022-3042 (Print)&#xD;0022-3042 (Linking)</isbn><accession-num>448355</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[199]) синтезируется в мозге из ГАМК и L-гистидина с помощью карнозин-синтетазы. Однако скорость синтеза гомокарнозина при прочих равных условиях гораздо медленнее, чем для карнозина PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ecm96YWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+MTU1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1LCA3XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE1NTwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RHJvemFrLCBKLjwvYXV0aG9yPjxhdXRo

b3I+VmVpZ2EtZGEtQ3VuaGEsIE0uPC9hdXRob3I+PGF1dGhvcj5WZXJ0b21tZW4sIEQuPC9hdXRo

b3I+PGF1dGhvcj5TdHJvb2JhbnQsIFYuPC9hdXRob3I+PGF1dGhvcj5WYW4gU2NoYWZ0aW5nZW4s

IEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TGFib3Jh

dG9yeSBvZiBQaHlzaW9sb2dpY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0ZSBDYXRob2xpcXVlIGRl

IExvdXZhaW4sIEF2ZW51ZSBIaXBwb2NyYXRlIDc1LCBCLTEyMDAgQnJ1c3NlbHMsIEJlbGdpdW0u

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TW9sZWN1bGFyIGlkZW50aWZpY2F0aW9uIG9m

IGNhcm5vc2luZSBzeW50aGFzZSBhcyBBVFAtZ3Jhc3AgZG9tYWluLWNvbnRhaW5pbmcgcHJvdGVp

biAxIChBVFBHRDEpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVt

PC9mdWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8

L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45MzQ2LTU2PC9wYWdlcz48dm9sdW1lPjI4

NTwvdm9sdW1lPjxudW1iZXI+MTM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzAxLzI2PC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgTW9ub3Bob3NwaGF0ZS9tZXRhYm9saXNtPC9r

ZXl3b3JkPjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvIGNoZW1pc3RyeTwva2V5d29y

ZD48a2V5d29yZD5BbGFuaW5lL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5BbWlubyBBY2lk

IFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fy

bm9zaW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBMaW5lPC9rZXl3b3JkPjxr

ZXl3b3JkPkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD5NYXNzIFNwZWN0cm9tZXRyeS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdv

cmQ+PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+UGVw

dGlkZSBTeW50aGFzZXMvIGdlbmV0aWNzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBl

cHRpZGVzL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBIb21vbG9neSwgQW1p

bm8gQWNpZDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+

PGtleXdvcmQ+Z2FtbWEtQW1pbm9idXR5cmljIEFjaWQvY2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXIgMjY8L2Rh

dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDgzLTM1MVggKEVsZWN0cm9uaWMpJiN4RDsw

MDIxLTkyNTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMDk3NzUyPC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMyODQzMTgzPC9jdXN0b20yPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMTA5LjA5NTUwNTwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5Ta2FwZXI8L0F1dGhvcj48WWVhcj4xOTczPC9ZZWFyPjxSZWNOdW0+MjY4PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4yNjg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjI2ODwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2thcGVyLCBTLiBELjwvYXV0

aG9yPjxhdXRob3I+RGFzLCBTLjwvYXV0aG9yPjxhdXRob3I+TWFyc2hhbGwsIEYuIEQuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlNvbWUgcHJvcGVydGll

cyBvZiBhIGhvbW9jYXJub3NpbmUtY2Fybm9zaW5lIHN5bnRoZXRhc2UgaXNvbGF0ZWQgZnJvbSBy

YXQgYnJhaW48L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBOZXVyb2NoZW08L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkpvdXJuYWwgb2YgbmV1cm9jaGVtaXN0cnk8L2FsdC10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIE5ldXJvY2hlbTwvZnVsbC10aXRsZT48YWJi

ci0xPkpvdXJuYWwgb2YgbmV1cm9jaGVtaXN0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1w

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogTmV1cm9jaGVtPC9mdWxsLXRpdGxlPjxhYmJyLTE+Sm91

cm5hbCBvZiBuZXVyb2NoZW1pc3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE0

MjktNDU8L3BhZ2VzPjx2b2x1bWU+MjE8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlv

bj4xOTczLzEyLzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgRGlwaG9z

cGhhdGUvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5BZGVu

b3NpbmUgTW9ub3Bob3NwaGF0ZS9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNh

dGlvbi9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkFsYW5pbmUvbWV0YWJvbGlzbTwva2V5

d29yZD48a2V5d29yZD5BbWlub2J1dHlyYXRlcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkFtbW9uaXVtIFN1bGZhdGU8L2tleXdvcmQ+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5

d29yZD5CcmFpbi8gZW56eW1vbG9neTwva2V5d29yZD48a2V5d29yZD5DYXJib24gUmFkaW9pc290

b3Blczwva2V5d29yZD48a2V5d29yZD5DaHJvbWF0b2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5D

aHJvbWF0b2dyYXBoeSwgUGFwZXI8L2tleXdvcmQ+PGtleXdvcmQ+RGlhbHlzaXM8L2tleXdvcmQ+

PGtleXdvcmQ+RGlwZXB0aWRlczwva2V5d29yZD48a2V5d29yZD5EaXBob3NwaGF0ZXMvbWV0YWJv

bGlzbTwva2V5d29yZD48a2V5d29yZD5FbGVjdHJvcGhvcmVzaXMsIFBhcGVyPC9rZXl3b3JkPjxr

ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IaXN0aWRpbmUvbWV0YWJvbGlzbTwva2V5

d29yZD48a2V5d29yZD5IeWRyb2dlbi1Jb24gQ29uY2VudHJhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5OQUQvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5OZXJ2

ZSBUaXNzdWUgUHJvdGVpbnMvYW5hbHlzaXMvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5QZXB0aWRlIFN5bnRoYXNlcy8gaXNvbGF0aW9uICZhbXA7IHB1cmlm

aWNhdGlvbi9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRpZGVzL2FuYWx5c2lzPC9r

ZXl3b3JkPjxrZXl3b3JkPlJhdHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MTk3

MzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxp

c2JuPjAwMjItMzA0MiAoUHJpbnQpJiN4RDswMDIyLTMwNDIgKExpbmtpbmcpPC9pc2JuPjxhY2Nl

c3Npb24tbnVtPjQzNTg4ODA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxyZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ecm96YWs8L0F1dGhvcj48WWVhcj4yMDEwPC9ZZWFyPjxS

ZWNOdW0+MTU1PC9SZWNOdW0+PERpc3BsYXlUZXh0Pls1LCA3XTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xNTU8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE1NTwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+RHJvemFrLCBKLjwvYXV0aG9yPjxhdXRo

b3I+VmVpZ2EtZGEtQ3VuaGEsIE0uPC9hdXRob3I+PGF1dGhvcj5WZXJ0b21tZW4sIEQuPC9hdXRo

b3I+PGF1dGhvcj5TdHJvb2JhbnQsIFYuPC9hdXRob3I+PGF1dGhvcj5WYW4gU2NoYWZ0aW5nZW4s

IEUuPC9hdXRob3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjxhdXRoLWFkZHJlc3M+TGFib3Jh

dG9yeSBvZiBQaHlzaW9sb2dpY2FsIENoZW1pc3RyeSwgVW5pdmVyc2l0ZSBDYXRob2xpcXVlIGRl

IExvdXZhaW4sIEF2ZW51ZSBIaXBwb2NyYXRlIDc1LCBCLTEyMDAgQnJ1c3NlbHMsIEJlbGdpdW0u

PC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+TW9sZWN1bGFyIGlkZW50aWZpY2F0aW9uIG9m

IGNhcm5vc2luZSBzeW50aGFzZSBhcyBBVFAtZ3Jhc3AgZG9tYWluLWNvbnRhaW5pbmcgcHJvdGVp

biAxIChBVFBHRDEpPC90aXRsZT48c2Vjb25kYXJ5LXRpdGxlPkogQmlvbCBDaGVtPC9zZWNvbmRh

cnktdGl0bGU+PGFsdC10aXRsZT5UaGUgSm91cm5hbCBvZiBiaW9sb2dpY2FsIGNoZW1pc3RyeTwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVtPC9m

dWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8L2Fi

YnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogQmlvbCBDaGVt

PC9mdWxsLXRpdGxlPjxhYmJyLTE+VGhlIEpvdXJuYWwgb2YgYmlvbG9naWNhbCBjaGVtaXN0cnk8

L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz45MzQ2LTU2PC9wYWdlcz48dm9sdW1lPjI4

NTwvdm9sdW1lPjxudW1iZXI+MTM8L251bWJlcj48ZWRpdGlvbj4yMDEwLzAxLzI2PC9lZGl0aW9u

PjxrZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgTW9ub3Bob3NwaGF0ZS9tZXRhYm9saXNtPC9r

ZXl3b3JkPjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvIGNoZW1pc3RyeTwva2V5d29y

ZD48a2V5d29yZD5BbGFuaW5lL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5BbWlubyBBY2lk

IFNlcXVlbmNlPC9rZXl3b3JkPjxrZXl3b3JkPkFuaW1hbHM8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fy

bm9zaW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+Q2VsbCBMaW5lPC9rZXl3b3JkPjxr

ZXl3b3JkPkNoaWNrZW5zPC9rZXl3b3JkPjxrZXl3b3JkPkh1bWFuczwva2V5d29yZD48a2V5d29y

ZD5NYXNzIFNwZWN0cm9tZXRyeS9tZXRob2RzPC9rZXl3b3JkPjxrZXl3b3JkPk1pY2U8L2tleXdv

cmQ+PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8L2tleXdvcmQ+PGtleXdvcmQ+UGVw

dGlkZSBTeW50aGFzZXMvIGdlbmV0aWNzLyBtZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBl

cHRpZGVzL2NoZW1pc3RyeTwva2V5d29yZD48a2V5d29yZD5TZXF1ZW5jZSBIb21vbG9neSwgQW1p

bm8gQWNpZDwva2V5d29yZD48a2V5d29yZD5TdWJzdHJhdGUgU3BlY2lmaWNpdHk8L2tleXdvcmQ+

PGtleXdvcmQ+Z2FtbWEtQW1pbm9idXR5cmljIEFjaWQvY2hlbWlzdHJ5PC9rZXl3b3JkPjwva2V5

d29yZHM+PGRhdGVzPjx5ZWFyPjIwMTA8L3llYXI+PHB1Yi1kYXRlcz48ZGF0ZT5NYXIgMjY8L2Rh

dGU+PC9wdWItZGF0ZXM+PC9kYXRlcz48aXNibj4xMDgzLTM1MVggKEVsZWN0cm9uaWMpJiN4RDsw

MDIxLTkyNTggKExpbmtpbmcpPC9pc2JuPjxhY2Nlc3Npb24tbnVtPjIwMDk3NzUyPC9hY2Nlc3Np

b24tbnVtPjx1cmxzPjwvdXJscz48Y3VzdG9tMj5QTUMyODQzMTgzPC9jdXN0b20yPjxlbGVjdHJv

bmljLXJlc291cmNlLW51bT4xMC4xMDc0L2piYy5NMTA5LjA5NTUwNTwvZWxlY3Ryb25pYy1yZXNv

dXJjZS1udW0+PHJlbW90ZS1kYXRhYmFzZS1wcm92aWRlcj5OTE08L3JlbW90ZS1kYXRhYmFzZS1w

cm92aWRlcj48bGFuZ3VhZ2U+ZW5nPC9sYW5ndWFnZT48L3JlY29yZD48L0NpdGU+PENpdGU+PEF1

dGhvcj5Ta2FwZXI8L0F1dGhvcj48WWVhcj4xOTczPC9ZZWFyPjxSZWNOdW0+MjY4PC9SZWNOdW0+

PHJlY29yZD48cmVjLW51bWJlcj4yNjg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFw

cD0iRU4iIGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjI2ODwv

a2V5PjwvZm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9y

ZWYtdHlwZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+U2thcGVyLCBTLiBELjwvYXV0

aG9yPjxhdXRob3I+RGFzLCBTLjwvYXV0aG9yPjxhdXRob3I+TWFyc2hhbGwsIEYuIEQuPC9hdXRo

b3I+PC9hdXRob3JzPjwvY29udHJpYnV0b3JzPjx0aXRsZXM+PHRpdGxlPlNvbWUgcHJvcGVydGll

cyBvZiBhIGhvbW9jYXJub3NpbmUtY2Fybm9zaW5lIHN5bnRoZXRhc2UgaXNvbGF0ZWQgZnJvbSBy

YXQgYnJhaW48L3RpdGxlPjxzZWNvbmRhcnktdGl0bGU+SiBOZXVyb2NoZW08L3NlY29uZGFyeS10

aXRsZT48YWx0LXRpdGxlPkpvdXJuYWwgb2YgbmV1cm9jaGVtaXN0cnk8L2FsdC10aXRsZT48L3Rp

dGxlcz48cGVyaW9kaWNhbD48ZnVsbC10aXRsZT5KIE5ldXJvY2hlbTwvZnVsbC10aXRsZT48YWJi

ci0xPkpvdXJuYWwgb2YgbmV1cm9jaGVtaXN0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1w

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkogTmV1cm9jaGVtPC9mdWxsLXRpdGxlPjxhYmJyLTE+Sm91

cm5hbCBvZiBuZXVyb2NoZW1pc3RyeTwvYWJici0xPjwvYWx0LXBlcmlvZGljYWw+PHBhZ2VzPjE0

MjktNDU8L3BhZ2VzPjx2b2x1bWU+MjE8L3ZvbHVtZT48bnVtYmVyPjY8L251bWJlcj48ZWRpdGlv

bj4xOTczLzEyLzAxPC9lZGl0aW9uPjxrZXl3b3Jkcz48a2V5d29yZD5BZGVub3NpbmUgRGlwaG9z

cGhhdGUvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5BZGVu

b3NpbmUgTW9ub3Bob3NwaGF0ZS9pc29sYXRpb24gJmFtcDsgcHVyaWZpY2F0aW9uPC9rZXl3b3Jk

PjxrZXl3b3JkPkFkZW5vc2luZSBUcmlwaG9zcGhhdGUvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNh

dGlvbi9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPkFsYW5pbmUvbWV0YWJvbGlzbTwva2V5

d29yZD48a2V5d29yZD5BbWlub2J1dHlyYXRlcy9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3Jk

PkFtbW9uaXVtIFN1bGZhdGU8L2tleXdvcmQ+PGtleXdvcmQ+QW5pbWFsczwva2V5d29yZD48a2V5

d29yZD5CcmFpbi8gZW56eW1vbG9neTwva2V5d29yZD48a2V5d29yZD5DYXJib24gUmFkaW9pc290

b3Blczwva2V5d29yZD48a2V5d29yZD5DaHJvbWF0b2dyYXBoeTwva2V5d29yZD48a2V5d29yZD5D

aHJvbWF0b2dyYXBoeSwgUGFwZXI8L2tleXdvcmQ+PGtleXdvcmQ+RGlhbHlzaXM8L2tleXdvcmQ+

PGtleXdvcmQ+RGlwZXB0aWRlczwva2V5d29yZD48a2V5d29yZD5EaXBob3NwaGF0ZXMvbWV0YWJv

bGlzbTwva2V5d29yZD48a2V5d29yZD5FbGVjdHJvcGhvcmVzaXMsIFBhcGVyPC9rZXl3b3JkPjxr

ZXl3b3JkPkZlbWFsZTwva2V5d29yZD48a2V5d29yZD5IaXN0aWRpbmUvbWV0YWJvbGlzbTwva2V5

d29yZD48a2V5d29yZD5IeWRyb2dlbi1Jb24gQ29uY2VudHJhdGlvbjwva2V5d29yZD48a2V5d29y

ZD5OQUQvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5OZXJ2

ZSBUaXNzdWUgUHJvdGVpbnMvYW5hbHlzaXMvaXNvbGF0aW9uICZhbXA7IHB1cmlmaWNhdGlvbjwv

a2V5d29yZD48a2V5d29yZD5QZXB0aWRlIFN5bnRoYXNlcy8gaXNvbGF0aW9uICZhbXA7IHB1cmlm

aWNhdGlvbi9tZXRhYm9saXNtPC9rZXl3b3JkPjxrZXl3b3JkPlBlcHRpZGVzL2FuYWx5c2lzPC9r

ZXl3b3JkPjxrZXl3b3JkPlJhdHM8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MTk3

MzwveWVhcj48cHViLWRhdGVzPjxkYXRlPkRlYzwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxp

c2JuPjAwMjItMzA0MiAoUHJpbnQpJiN4RDswMDIyLTMwNDIgKExpbmtpbmcpPC9pc2JuPjxhY2Nl

c3Npb24tbnVtPjQzNTg4ODA8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxyZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT5=

ADDIN EN.CITE.DATA [5, 7]. Синтез анзерина (до 40 мМ в мышцах птиц ADDIN EN.CITE <EndNote><Cite><Author>Crush</Author><Year>1970</Year><RecNum>265</RecNum><DisplayText>[200]</DisplayText><record><rec-number>265</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">265</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author>Crush, K. G.</author></authors></contributors><titles><title>Carnosine and related substances in animal tissues</title><secondary-title>Comp Biochem Physiol</secondary-title><alt-title>Comparative biochemistry and physiology</alt-title></titles><periodical><full-title>Comp Biochem Physiol</full-title><abbr-1>Comparative biochemistry and physiology</abbr-1></periodical><alt-periodical><full-title>Comp Biochem Physiol</full-title><abbr-1>Comparative biochemistry and physiology</abbr-1></alt-periodical><pages>3-30</pages><volume>34</volume><number>1</number><edition>1970/05/01</edition><keywords><keyword>Alanine/analysis</keyword><keyword>Aminobutyrates/analysis</keyword><keyword>Amphibians</keyword><keyword>Animals</keyword><keyword>Birds</keyword><keyword>Cats</keyword><keyword>Cattle</keyword><keyword>Chromatography, Paper</keyword><keyword>Dipeptides/ analysis</keyword><keyword>Dogs</keyword><keyword>Haplorhini</keyword><keyword>Histidine/analysis</keyword><keyword>Mammals</keyword><keyword>Muscles/analysis</keyword><keyword>Postmortem Changes</keyword><keyword>Rabbits</keyword><keyword>Reptiles</keyword><keyword>Skin/analysis</keyword><keyword>Tissue Extracts/analysis</keyword></keywords><dates><year>1970</year><pub-dates><date>May 1</date></pub-dates></dates><isbn>0010-406X (Print)&#xD;0010-406X (Linking)</isbn><accession-num>4988625</accession-num><urls></urls><remote-database-provider>NLM</remote-database-provider><language>eng</language></record></Cite></EndNote>[200]) происходит в мышцах позвоночных животных путем метилирования карнозина с помощью метилтрансферазы ADDIN EN.CITE <EndNote><Cite><Author>I.R.</Author><Year>1962</Year><RecNum>157</RecNum><DisplayText>[201]</DisplayText><record><rec-number>157</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">157</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author> I.R., McManus</author></authors></contributors><titles><title>Enzymatic synthesis of anserine in skeletal muscle by N-methylation of carnosine</title><secondary-title>The Journal of Biological Chemistry </secondary-title></titles><periodical><full-title>J Biol Chem</full-title><abbr-1>The Journal of biological chemistry</abbr-1></periodical><pages>1207-1211</pages><volume>237</volume><section>1207</section><dates><year>1962</year></dates><urls></urls></record></Cite></EndNote>[201]. Анзерин не обнаружен в организме человека. Расщепление производных карнозина осуществляет сывороточная карнозиназа (CN1), при этом скорость гидролиза гомокарнозина составляет 11% от скорости гидролиза карнозина или анзерина PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYWNrc29uPC9BdXRob3I+PFllYXI+MTk5MTwvWWVhcj48

UmVjTnVtPjE5ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjAyXTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xOTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE5ODwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SmFja3NvbiwgTS4gQy48L2F1dGhvcj48

YXV0aG9yPkt1Y2VyYSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPkxlbm5leSwgSi4gRi48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5QaGFybWFjb2xvZ3kgRGVw

YXJ0bWVudCwgU2Nob29sIG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIEhhd2FpaSwgSG9ub2x1

bHUgOTY4MjIuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UHVyaWZpY2F0aW9uIGFuZCBw

cm9wZXJ0aWVzIG9mIGh1bWFuIHNlcnVtIGNhcm5vc2luYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gQ2hpbSBBY3RhPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DbGluaWNhIGNo

aW1pY2EgYWN0YTsgaW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIGNsaW5pY2FsIGNoZW1pc3RyeTwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gQ2hpbSBBY3Rh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbmljYSBjaGltaWNhIGFjdGE7IGludGVybmF0aW9uYWwg

am91cm5hbCBvZiBjbGluaWNhbCBjaGVtaXN0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1w

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gQ2hpbSBBY3RhPC9mdWxsLXRpdGxlPjxhYmJyLTE+

Q2xpbmljYSBjaGltaWNhIGFjdGE7IGludGVybmF0aW9uYWwgam91cm5hbCBvZiBjbGluaWNhbCBj

aGVtaXN0cnk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xOTMtMjA1PC9wYWdlcz48

dm9sdW1lPjE5Njwvdm9sdW1lPjxudW1iZXI+Mi0zPC9udW1iZXI+PGVkaXRpb24+MTk5MS8wMi8x

NTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdv

cmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5d29yZD5BbmltYWxzPC9rZXl3b3Jk

PjxrZXl3b3JkPkFuc2VyaW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+QnJhaW4vIGVu

enltb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9zaW5lL2FuYWxvZ3MgJmFtcDsgZGVyaXZh

dGl2ZXMvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5DaHJvbWF0b2dyYXBoeSwgREVBRS1D

ZWxsdWxvc2U8L2tleXdvcmQ+PGtleXdvcmQ+Q3JpY2V0aW5hZTwva2V5d29yZD48a2V5d29yZD5E

aXBlcHRpZGFzZXMvIGJsb29kL2NlcmVicm9zcGluYWwgZmx1aWQvaXNvbGF0aW9uICZhbXA7IHB1

cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5FbGVjdHJvcGhvcmVzaXMsIFBvbHlhY3J5bGFt

aWRlIEdlbDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+R2x5Y29w

cm90ZWlucy9hbmFseXNpczwva2V5d29yZD48a2V5d29yZD5IYXBsb3JoaW5pL21ldGFib2xpc208

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPklzb2VsZWN0cmljIEZv

Y3VzaW5nPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWVzb2NyaWNl

dHVzL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8

L2tleXdvcmQ+PGtleXdvcmQ+TXVzY2xlcy9lbnp5bW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlNw

ZWNpZXMgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MTk5MTwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxNTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxp

c2JuPjAwMDktODk4MSAoUHJpbnQpJiN4RDswMDA5LTg5ODEgKExpbmtpbmcpPC9pc2JuPjxhY2Nl

c3Npb24tbnVtPjE5MDMwOTU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxyZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5KYWNrc29uPC9BdXRob3I+PFllYXI+MTk5MTwvWWVhcj48

UmVjTnVtPjE5ODwvUmVjTnVtPjxEaXNwbGF5VGV4dD5bMjAyXTwvRGlzcGxheVRleHQ+PHJlY29y

ZD48cmVjLW51bWJlcj4xOTg8L3JlYy1udW1iZXI+PGZvcmVpZ24ta2V5cz48a2V5IGFwcD0iRU4i

IGRiLWlkPSJ3MndmeGFmZTZ2YTl6NWVldjJsNTVhYThzeHNhNTk5ZWV2MnMiPjE5ODwva2V5Pjwv

Zm9yZWlnbi1rZXlzPjxyZWYtdHlwZSBuYW1lPSJKb3VybmFsIEFydGljbGUiPjE3PC9yZWYtdHlw

ZT48Y29udHJpYnV0b3JzPjxhdXRob3JzPjxhdXRob3I+SmFja3NvbiwgTS4gQy48L2F1dGhvcj48

YXV0aG9yPkt1Y2VyYSwgQy4gTS48L2F1dGhvcj48YXV0aG9yPkxlbm5leSwgSi4gRi48L2F1dGhv

cj48L2F1dGhvcnM+PC9jb250cmlidXRvcnM+PGF1dGgtYWRkcmVzcz5QaGFybWFjb2xvZ3kgRGVw

YXJ0bWVudCwgU2Nob29sIG9mIE1lZGljaW5lLCBVbml2ZXJzaXR5IG9mIEhhd2FpaSwgSG9ub2x1

bHUgOTY4MjIuPC9hdXRoLWFkZHJlc3M+PHRpdGxlcz48dGl0bGU+UHVyaWZpY2F0aW9uIGFuZCBw

cm9wZXJ0aWVzIG9mIGh1bWFuIHNlcnVtIGNhcm5vc2luYXNlPC90aXRsZT48c2Vjb25kYXJ5LXRp

dGxlPkNsaW4gQ2hpbSBBY3RhPC9zZWNvbmRhcnktdGl0bGU+PGFsdC10aXRsZT5DbGluaWNhIGNo

aW1pY2EgYWN0YTsgaW50ZXJuYXRpb25hbCBqb3VybmFsIG9mIGNsaW5pY2FsIGNoZW1pc3RyeTwv

YWx0LXRpdGxlPjwvdGl0bGVzPjxwZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gQ2hpbSBBY3Rh

PC9mdWxsLXRpdGxlPjxhYmJyLTE+Q2xpbmljYSBjaGltaWNhIGFjdGE7IGludGVybmF0aW9uYWwg

am91cm5hbCBvZiBjbGluaWNhbCBjaGVtaXN0cnk8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1w

ZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkNsaW4gQ2hpbSBBY3RhPC9mdWxsLXRpdGxlPjxhYmJyLTE+

Q2xpbmljYSBjaGltaWNhIGFjdGE7IGludGVybmF0aW9uYWwgam91cm5hbCBvZiBjbGluaWNhbCBj

aGVtaXN0cnk8L2FiYnItMT48L2FsdC1wZXJpb2RpY2FsPjxwYWdlcz4xOTMtMjA1PC9wYWdlcz48

dm9sdW1lPjE5Njwvdm9sdW1lPjxudW1iZXI+Mi0zPC9udW1iZXI+PGVkaXRpb24+MTk5MS8wMi8x

NTwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+QWdlIEZhY3RvcnM8L2tleXdvcmQ+PGtleXdv

cmQ+QW1pbm8gQWNpZCBTZXF1ZW5jZTwva2V5d29yZD48a2V5d29yZD5BbmltYWxzPC9rZXl3b3Jk

PjxrZXl3b3JkPkFuc2VyaW5lL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+QnJhaW4vIGVu

enltb2xvZ3k8L2tleXdvcmQ+PGtleXdvcmQ+Q2Fybm9zaW5lL2FuYWxvZ3MgJmFtcDsgZGVyaXZh

dGl2ZXMvbWV0YWJvbGlzbTwva2V5d29yZD48a2V5d29yZD5DaHJvbWF0b2dyYXBoeSwgREVBRS1D

ZWxsdWxvc2U8L2tleXdvcmQ+PGtleXdvcmQ+Q3JpY2V0aW5hZTwva2V5d29yZD48a2V5d29yZD5E

aXBlcHRpZGFzZXMvIGJsb29kL2NlcmVicm9zcGluYWwgZmx1aWQvaXNvbGF0aW9uICZhbXA7IHB1

cmlmaWNhdGlvbjwva2V5d29yZD48a2V5d29yZD5FbGVjdHJvcGhvcmVzaXMsIFBvbHlhY3J5bGFt

aWRlIEdlbDwva2V5d29yZD48a2V5d29yZD5GZW1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+R2x5Y29w

cm90ZWlucy9hbmFseXNpczwva2V5d29yZD48a2V5d29yZD5IYXBsb3JoaW5pL21ldGFib2xpc208

L2tleXdvcmQ+PGtleXdvcmQ+SHVtYW5zPC9rZXl3b3JkPjxrZXl3b3JkPklzb2VsZWN0cmljIEZv

Y3VzaW5nPC9rZXl3b3JkPjxrZXl3b3JkPk1hbGU8L2tleXdvcmQ+PGtleXdvcmQ+TWVzb2NyaWNl

dHVzL21ldGFib2xpc208L2tleXdvcmQ+PGtleXdvcmQ+TW9sZWN1bGFyIFNlcXVlbmNlIERhdGE8

L2tleXdvcmQ+PGtleXdvcmQ+TXVzY2xlcy9lbnp5bW9sb2d5PC9rZXl3b3JkPjxrZXl3b3JkPlNw

ZWNpZXMgU3BlY2lmaWNpdHk8L2tleXdvcmQ+PC9rZXl3b3Jkcz48ZGF0ZXM+PHllYXI+MTk5MTwv

eWVhcj48cHViLWRhdGVzPjxkYXRlPkZlYiAxNTwvZGF0ZT48L3B1Yi1kYXRlcz48L2RhdGVzPjxp

c2JuPjAwMDktODk4MSAoUHJpbnQpJiN4RDswMDA5LTg5ODEgKExpbmtpbmcpPC9pc2JuPjxhY2Nl

c3Npb24tbnVtPjE5MDMwOTU8L2FjY2Vzc2lvbi1udW0+PHVybHM+PC91cmxzPjxyZW1vdGUtZGF0

YWJhc2UtcHJvdmlkZXI+TkxNPC9yZW1vdGUtZGF0YWJhc2UtcHJvdmlkZXI+PGxhbmd1YWdlPmVu

ZzwvbGFuZ3VhZ2U+PC9yZWNvcmQ+PC9DaXRlPjwvRW5kTm90ZT4A

ADDIN EN.CITE.DATA [202].

Рисунок 1.5.

Структура карнозина и его производных. Из ADDIN EN.CITE <EndNote><Cite><RecNum>344</RecNum><DisplayText>[203]</DisplayText><record><rec-number>344</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">344</key></foreign-keys><ref-type name="Electronic Article">43</ref-type><contributors></contributors><titles><title>ChemSpider Free chemical structure database, www.chemspider.com&#xD;</title></titles><dates></dates><urls></urls></record></Cite></EndNote>[203] изменениями.

В организме человека карнозин выполняет множество функций, среди которых: pH-буфер в мышцах ADDIN EN.CITE <EndNote><Cite><Author>Северин С. Е.</Author><Year>1953</Year><RecNum>200</RecNum><DisplayText>[10]</DisplayText><record><rec-number>200</rec-number><foreign-keys><key app="EN" db-id="w2wfxafe6va9z5eev2l55aa8sxsa599eev2s">200</key></foreign-keys><ref-type name="Journal Article">17</ref-type><contributors><authors><author><style face="normal" font="default" charset="204" size="100%">Северин С. Е., Кирзон, М.В., Кафтанова, Т.М.</style></author></authors></contributors><titles><title><style face="normal" font="default" charset="204" size="100%">Влияние карнозина и ансерина на работу изолированной мышцы лягушки.</style></title><secondary-title><style face="normal" font="default" charset="204" size="100%">Доклад. АН СССР</style></secondary-title></titles><periodical><full-title>Доклад. АН СССР</full-title></periodical><pages><style face="normal" font="default" charset="204" size="100%">691-694</style></pages><volume><style face="normal" font="default" charset="204" size="100%">91</style></volume><dates><year><style face="normal" font="default" charset="204" size="100%">1953</style></year></dates><urls></urls></record></Cite></EndNote>[10], хелатор металлов переменной валентности (Fe, Cu, Zn, Co) PEVuZE5vdGU+PENpdGU+PEF1dGhvcj5Ccm93bjwvQXV0aG9yPjxZZWFyPjE5Nzk8L1llYXI+PFJl

Y051bT4xNDI8L1JlY051bT48RGlzcGxheVRleHQ+WzExLTEzLCAyMDQsIDIwNV08L0Rpc3BsYXlU

ZXh0PjxyZWNvcmQ+PHJlYy1udW1iZXI+MTQyPC9yZWMtbnVtYmVyPjxmb3JlaWduLWtleXM+PGtl

eSBhcHA9IkVOIiBkYi1pZD0idzJ3ZnhhZmU2dmE5ejVlZXYybDU1YWE4c3hzYTU5OWVldjJzIj4x

NDI8L2tleT48L2ZvcmVpZ24ta2V5cz48cmVmLXR5cGUgbmFtZT0iSm91cm5hbCBBcnRpY2xlIj4x

NzwvcmVmLXR5cGU+PGNvbnRyaWJ1dG9ycz48YXV0aG9ycz48YXV0aG9yPkJyb3duLCBDLiBFLjwv

YXV0aG9yPjxhdXRob3I+QW50aG9saW5lLCBXLiBFLjwvYXV0aG9yPjwvYXV0aG9ycz48L2NvbnRy

aWJ1dG9ycz48dGl0bGVzPjx0aXRsZT5NdWx0aXBsZSBmb3JtcyBvZiB0aGUgY29iYWx0KElJKS1j

YXJub3NpbmUgY29tcGxleDwvdGl0bGU+PHNlY29uZGFyeS10aXRsZT5CaW9jaGVtIEJpb3BoeXMg

UmVzIENvbW11bjwvc2Vjb25kYXJ5LXRpdGxlPjxhbHQtdGl0bGU+QmlvY2hlbWljYWwgYW5kIGJp

b3BoeXNpY2FsIHJlc2VhcmNoIGNvbW11bmljYXRpb25zPC9hbHQtdGl0bGU+PC90aXRsZXM+PHBl

cmlvZGljYWw+PGZ1bGwtdGl0bGU+QmlvY2hlbSBCaW9waHlzIFJlcyBDb21tdW48L2Z1bGwtdGl0

bGU+PGFiYnItMT5CaW9jaGVtaWNhbCBhbmQgYmlvcGh5c2ljYWwgcmVzZWFyY2ggY29tbXVuaWNh

dGlvbnM8L2FiYnItMT48L3BlcmlvZGljYWw+PGFsdC1wZXJpb2RpY2FsPjxmdWxsLXRpdGxlPkJp

b2NoZW0gQmlvcGh5cyBSZXMgQ29tbXVuPC9mdWxsLXRpdGxlPjxhYmJyLTE+QmlvY2hlbWljYWwg

YW5kIGJpb3BoeXNpY2FsIHJlc2VhcmNoIGNvbW11bmljYXRpb25zPC9hYmJyLTE+PC9hbHQtcGVy

aW9kaWNhbD48cGFnZXM+NTI5LTM2PC9wYWdlcz48dm9sdW1lPjg4PC92b2x1bWU+PG51bWJlcj4y

PC9udW1iZXI+PGVkaXRpb24+MTk3OS8wNS8yODwvZWRpdGlvbj48a2V5d29yZHM+PGtleXdvcmQ+

Q2Fybm9zaW5lPC9rZXl3b3JkPjxrZXl3b3JkPkNoZW1pY2FsIFBoZW5vbWVuYTwva2V5d29yZD48

a2V5d29yZD5DaGVtaXN0cnk8L2tleXdvcmQ+PGtleXdvcmQ+Q29iYWx0PC9rZXl3b3JkPjxrZXl3

b3JkPkRpcGVwdGlkZXM8L2tleXdvcmQ+PGtleXdvcmQ+TGlnYW5kczwva2V5d29yZD48L2tleXdv



Pages:     | 1 |   ...   | 8 | 9 || 11 | 12 |   ...   | 17 |
Похожие работы:

«Приложение           к постановлению Правительства Республики Казахстан от " " 2017 года № Утверждены          постановлением Правительства Республики Казахстан от 30 декабря 2013 года № 1434 Основные положения Генеральной схемы организации территории Республики Казахстан Содержа...»

«Республиканское государственное казенное учреждение "Учебно – методический центр экологической безопасности и защиты населения" Методические рекомендации Безопасные весенние каникулы Йошкар-Ола 2015 № п/п Наименование учреждения телефон 1 Единая дежурно-диспетчерская служба 112 2 Полиция 02 3 Станция скорой медицинской помощи 03...»

«УДК 33:66 Экономическая эффективность плазмохимического метода переработки промышленных и бытовых отходов В.Ю. Рогов, А.В. Зарецкий, Ж.И. Лобанова, М.А. Макаров Национальный исследовательский Иркутский государственный технический университет, 664074, г. Иркутск, ул. Лермонтова, 83. С каждым днем становится все актуальней проблема огром...»

«Авторы: В. Г. Сикерин, В. И. Погорелов, Н. Е. Шалабот, В. М. Севодняев, С. В. Колчин, А. С. Семенов, В. В. Гурдин, В. М. Касимов, Н. В. Костицина, А. Н. Шарипов, А. Ю. Камалов, М. Л. Дычек, С. В. Бочкарев Кинологическое обеспечени...»

«Тема : Что нас окружает. Живая и неживая природа, изделия человека. Цель: сформировать у учащихся понятия о живом и неживом в природе и о рукотворном мире ; формировать умения классифицировать предметы; формировать навык соотнесения реального объекта и его условного обозначения ; сформировать нача...»

«Год экологии 2017: план мероприятий в школе ГБОУ №5 Центрального района Куратор Фомина В.В. учитель географии Цель: формирование активной гражданской позиции в сфере экологии у школьников.  Наименование мероприятия Сроки проведения Ответс...»

«Предварительная Экологическая Оценка KAZ: ЦАРЭС Коридор 2 (участки Мангистауской Области) Жетыбай-Жанаозен 0-73 км Окончательная версия 18 мая 2015г Подготовлен Комитетом Автомобильных дорог Министерства по Инвестициям и...»

«19.12.2014 EN Official Journal of the European Union L 365/97 ИСПОЛНИТЕЛЬНЫЙ РЕГЛАМЕНТ КОМИССИИ (ЕС) No 1358/2014 от 18 декабря 2014 года, вносящий изменения в Регламент (EC) No 889/2008, устанавливающий подробные правила выполнения Регламе...»

«СТРАТЕГИЧЕСКАЯ ПРОГРАММА ИССЛЕДОВАНИЙТЕХНОЛОГИЧЕСКАЯ ПЛАТФОРМА"МАЛАЯ РАСПРЕДЕЛЕННАЯ ЭНЕРГЕТИКА" Москва, 2012СОДЕРЖАНИЕВВЕДЕНИЕ1. ТЕНДЕНЦИИ РАЗВИТИЯ РЫНКА И ТЕХНОЛОГИЙ В СФЕРЕ МАЛОЙ ЭНЕРГЕТИКИ 1.1. Законодательное обеспечение платформы 1.2. Оценка текущего положения на рынке (доля малой энергетики в балан...»

«ТЕСТЫ ПО МЕДИЦИНСКОЙ БИОЛОГИИ К ИТОГОВОМУ МОДУЛНОМУ КОНТРОЛЮ № 1 ДЛЯ СТУДЕНТОВ 1 КУРСА I-V МЕДИЦИНСКИХ ФАКУЛЬТЕТОВ 2014-2015 УЧ.ГОД1. Поддержание жизни на любом уровне связано с явлением репродукции. На каком уровне организации репродукция осуществляе...»

«МИНИСТЕРСТВО ОБРАЗОВАНИЯ И НАУКИ РОССИЙСКОЙ ФЕДЕРАЦИИ ФГБОУ ВО Новосибирский национальный исследовательский государственный университет Факультет естественных наук УТВЕРЖДАЮ 75374540005 2306955106045Декан ФЕН НГУ, п...»

«ФЕДЕРАЛЬНАЯ СЛУЖБАПО ЭКОЛОГИЧЕСКОМУ, ТЕХНОЛОГИЧЕСКОМУ И АТОМНОМУ НАДЗОРУ (РОСТЕХНАДЗОР)ПРИКАЗ № _ Москва О внесении изменений в Административный регламент Федеральной службы по экологическому, технологическому и атомному надзору по предоставлению государственной услуги по ведению реестра заключений экспертизы промышленной безо...»

«Колотикова Анна Михайловна Московский государственный университет имени М.В. Ломоносова Факультет иностранных языков и регионоведения e-mail: alucardy@list.ru Anna M. Kolotik...»

«"Утверждаю" Зав. кафедрой общего землеведения и гидрометеорологии _П.С.Лопух " 29_"_ноября2016 г., пр. № 4 Вопросы к зачету по дисциплине "Мониторинг атмосферного воздуха и гидросферы" Мониторинг природной среды и мониторинг окружающей среды: основные различия и сходства. Место системы мониторинга о...»

«Реферат Борисовец Мария Николаевна "Агроэкотуризм в Гродненской области Республики Беларусь" Ключевые слова: состояние агроэкотуризма, агроэкотуристический потенциал, программы, проекты, туристические кластеры, виды услуг, проблемы и перспективы развития. Урбанизация, неблагоприятная экол...»

«РЕФЕРАТ "Воздействие тяжелых металлов на природу и здоровье человека" Реферат подготовил ученик "_" класса школы №_ _ План Введение Тяжелые металлы Биологическая роль Загрязнение тяжелыми металлами Ртуть Свинец Кадмий и цинк С...»

«3. ТИПИЗАЦИЯ УГЛЕСОДЕРЖАЩИХ ТЕРРИКОНОВ3.1. Анализ, систематизация и обобщение материалов предыдущих исследований По породным отвалам накоплен значительный объем разнообразных материалов. В научно-исследовательских трудах Алехина В.И., Мигули П.С., Проскурни Ю.А., Выборова С.Г., Панова Б.С., З...»

«Коваленко Галина Ивановна, доцент кафедры естественно-научного и математического образования (из опыта работы учителей: Маклаковой Оксаны Анатольевны, учителя биологии, географии МОУ "ООШ №34" г. Сыктывкара; Жидковой Валентины Викторовны, учителя географии МБ...»

«Certification File n° FORMTEXT Бланк заявки на сертификацию идентификационная карточка организации Application form / Company Identity Card1COMPANY DETAILS / РЕКВИЗИТЫ КОМПАНИИНазвание компании:Corporate Name: FORMTEXT Принадлежность к Группе:Affiliation to a Group: FORMTEXT Сфера деятельности: Sector of activity: FORMTEXT Код д...»

«ВОДНЫЙ МАРШРУТ по р. "ЩАРА" Старт сплава от д. Трафимовичи Дятловского района до д. Мосты Правые Мостовского района, с протяженностью – 42км. и продолжительностью 3 дня. Разработан маршрут совместно с лидской туристической фирмой "Святовид". Маршрут относится к классу "похода выходного дня" наиболее востребов...»

«УТВЕРЖДАЮ: Т.И. Крикунова Директор МБОУ Хомутовской СОШ № 12 Расписание уроков 2014 2015 учебный год 1 смена День недели № урока Звонки 1 класс 2 класс 3 класс 4 класс 9 класс 11 класс Понедельник 1 8.00 – 8.40 Физическая культура Русский язык Математика Литературное чтение Биология Физическая культура 2 8.45 – 9.25...»

«ТЕСТИ ОДД1. Тести одд Экология хамчун фан. Муносибати мутакобилаи организмхо бо биосфера. Мачмуи организми зинда ва муносибати мутакобилаи он бо мухити зист Мачмуи организми зинда ва муносибати му...»

«ОАО "Центр благоустройства и обращения с отходами" _УТВЕРЖДАЮ Глава городского округа В.И. Хлыста "_"_ 2010г. ТО Роспотребнадзора в Саткинском районе _ "_"_ 2010г. ОТЧЕТ О НАУЧНО-ИССЛЕДОВАТЕЛЬСКОЙ РАБОТЕ ПО ТЕМЕ: ГЕНЕРАЛЬНАЯ СХЕМА ОЧИСТКИ ТЕРРИТОРИИ НАСЕ...»

«Департамент природных ресурсов, экологии и агропромышленного комплекса Ненецкого автономного округа Казенное учреждение Ненецкого автономного округа "Центр природопользования и охраны окружающей среды"ДОКЛАД о состоянии окружающей среды в Ненецком автономном округев 2014 го...»

«Челябинская область Муниципальное бюджетное учреждение "Центр методического и хозяйственного обеспечения" от 12.12.2012г. Аналитическая справка по итогам проведения школьного этапа всероссийской олимпиады школьников в 2012-2013 уч. г.В период с 1 о...»

«Муниципальный этап всероссийской олимпиады школьников по обществознанию 2015/2016 учебный год Задания с ключами и критериями оценивания для 7 класса Задание № 11. Что объединя...»

«Киселёва Татьяна Игоревна, учитель биологии первой категории МАОУ "СОШ № 7" г. Сорочинска Предмет: биология Класс: 11 УМК: Сивоглазов В. И. Биология. Общая биология. Базовый уровень: учеб. Для 10-11 кл. общеобразовательных учреждений /В. И. Сивоглазов, И. Б. Агафонова, Е. Т. Захаров...»

«Урок 1 10 класс Тема урока Введение Цель Формирование знаний о медицинскойгеографии как науке о здоровье человека Задачи Обеспечить в ходе урока усвоение учащимися понятия медицинская география, предмет и методы ее исследования; Продолжить развитие у учащихся познавательного интереса, стремления к самостоятельному поиску знаний, стимулирование твор...»

«Классификация наук по предмету исследования По предмету исследования все науки делятся на естественные, гуманитарные и технические. Естественные науки изучают явления, процессы и объекты материального мира. Этот мир иногда называется внешним миром. К данным наукам относятся физика, химия, геология,...»








 
2017 www.li.i-docx.ru - «Бесплатная электронная библиотека - различные ресурсы»

Материалы этого сайта размещены для ознакомления, все права принадлежат их авторам.
Если Вы не согласны с тем, что Ваш материал размещён на этом сайте, пожалуйста, напишите нам, мы в течении 1-2 рабочих дней удалим его.